Academic Journal
Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice
| العنوان: | Endogenous control of inflammatory visceral pain by T cell‐derived opioids in IL‐10‐deficient mice |
|---|---|
| المؤلفون: | Basso, Lilian, Benamar, Mehdi, Mas‐orea, Xavier, Deraison, Céline, Blanpied, Catherine, Cenac, Nicolas, Saoudi, Abdelhadi, Dietrich, Gilles, Mas-Orea, Xavier |
| المساهمون: | Institut de Recherche en Santé Digestive (IRSD), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Physiopathologie Toulouse Purpan (CPTP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), ANR-11-EQPX-0003,ANINFIMIP,Equipements plateforme animalerie infectieuse de haute-sécurité de Midi Pyrénées(2011) |
| المصدر: | ISSN: 1350-1925. |
| بيانات النشر: | CCSD Wiley |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | IL10−/− mice, T lymphocytes, intestinal inflammation, opioids, visceral pain, MESH: Animals, MESH: CD4-Positive T-Lymphocytes / immunology, MESH: Visceral Pain / etiology, MESH: Visceral Pain / immunology, MESH: Colitis / complications, MESH: Colitis / immunology, MESH: Inflammation / complications, MESH: Inflammation / immunology, MESH: Interleukin-10 / deficiency, MESH: Intestinal Mucosa / immunology, MESH: Intestinal Mucosa / metabolism, MESH: Male, MESH: Mice, Inbred C57BL, MESH: Opioid Peptides / immunology, [SDV]Life Sciences [q-bio], [SDV.IMM]Life Sciences [q-bio]/Immunology, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology |
| الوصف: | International audience ; Background: The opioid-mediated analgesic activity of mucosal CD4+ T lymphocytes in colitis has been reported in immunocompetent mice so far. Here, we investigated whether CD4+ T lymphocytes alleviate from inflammation-induced abdominal pain in mice with defective immune regulation.Methods: Endogenous control of visceral pain by opioids locally produced in inflamed mucosa was assessed in IL-10-deficient mice.Key results: CD4+ T lymphocytes but not F4/80+ macrophages isolated from the lamina propria of IL-10-deficient mice with colitis express enkephalin-containing opioid peptides as assessed by cytofluorometry. Colitis in IL-10-/- mice was not associated with abdominal pain. Intraperitoneal injection of naloxone-methiodide, a peripheral opioid receptor antagonist, induced abdominal hypersensitivity in IL-10-/- mice with colitis.Conclusion and inferences: Opioid-mediated analgesic activity of mucosal T lymphocytes remains operating in IL-10-/- mice with impaired immune regulation. The data suggest that endogenous T cell-derived opioids might reduce inflammation-induced abdominal pain in inflammatory bowel diseases associated with homozygous "loss of function mutations" in interleukin-10. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31588671; PUBMED: 31588671; WOS: 000511174500005 |
| DOI: | 10.1111/nmo.13743 |
| الاتاحة: | https://hal.science/hal-03026676 https://hal.science/hal-03026676v1/document https://hal.science/hal-03026676v1/file/Basso%20et%20al.,%20manuscript.pdf https://doi.org/10.1111/nmo.13743 |
| Rights: | http://hal.archives-ouvertes.fr/licences/copyright/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.AA211692 |
| قاعدة البيانات: | BASE |
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