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Suboptimal use of non-vitamin K antagonist oral anticoagulants: Results from the RAMSES study

التفاصيل البيبلوغرافية
العنوان: Suboptimal use of non-vitamin K antagonist oral anticoagulants: Results from the RAMSES study
المؤلفون: Basaran, Ozcan, Dogan, Volkan, Beton, Osman, Tekinalp, Mehmet, Aykan, Ahmet Cagri, Kalaycioglu, Ezgi, Bolat, Ismail, Tasar, Onur, Safak, Ozgen, Kalcik, Macit, Yaman, Mehmet, Inci, Sinan, Altintas, Bernas, Kalkan, Sedat, Kirma, Cevat, Biteker, Murat, Karadeniz, Fatma Ozpamuk, Tekkesin, Ahmet Ilker, Cakilli, Yasin, Turkkan, Ceyhan, Hamidi, Mehmet, Demir, Vahit, Gursoy, Mustafa Ozan, Ozturk, Mujgan Tek, Aksan, Gokhan, Seyis, Sabri, Balli, Mehmet, Alici, Mehmet Hayri, Bozyel, Serdar, Altun, Ibrahim, Calik, Feyza, Karaca, Oguz, Helvaci, Fusun, Akay, Kadriye, Canga, Yigit, Celebi, Savas, Altuntas, Emine, Ayturk, Mehmet, Gunes, Haci Murat, Bezgin, Tahir, Aksakal, Aytekin, Cakal, Beytullah, Colak, Ayse, Kaplan, Ozgur, Tatlisu, Adem, Gozubuyuk, Gokhan, Demirelli, Selami, Kaya, Adnan, Rencuzogullari, Ibrahim, Bayram, Zubeyde, Simsek, Zeki, Civan, Murat, Batgharel, Ulaankhu, Ata, Ali Ekber, Gol, Gokhan, Mert, Gurbet Ozge, Mert, Kadir Ugur, Degirmencioglu, Aleks, Candan, Ozkan, Celebi, Ozlem Ozcan, Dogan, Cem, Yavuz, Fethi, Ulucan, Seref, Arisoy, Arif, Sahin, Bingul Dilekci, Ermis, Emrah, Gokaslan, Serkan, Pektas, Idris, Tanindi, Asli, Tekin, Kamuran, Sancar, Kadriye Memic, Cekic, Edip Guvenc, Basaran, Nesrin Filiz
المساهمون: Karadeniz, Fatma Ozpamuk Sanliurfa Balikligol State Hosp, Dept Cardiol, Merkez Sanliurfa, Turkey -- Tekkesin, Ahmet Ilker -- Turkkan, Ceyhan -- Cakal, Beytullah Siyami Ersek Heart Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- Cakilli, Yasin Tuzla State Hosp, Dept Cardiol, Tuzla Istanbul, Turkey -- Hamidi, Mehmet Bandirma State Hosp, Dept Cardiol, Balikesir, Turkey -- Demir, Vahit Yozgat State Hosp, Dept Cardiol, Yozgat, Turkey -- Gursoy, Mustafa Ozan Gaziemir State Hosp, Dept Cardiol, Gaziemir, Turkey -- Ozturk, Mujgan Tek -- Ayturk, Mehmet Ankara Kecioren Educ & Res Hosp, Dept Cardiol, Ankara, Turkey -- Aksan, Gokhan -- Helvaci, Fusun Sisli Hamidiye Etfal Educ & Res Hosp, Dept Cardiol, Sisli, Turkey -- Seyis, Sabri Mersin Private Dogus Hosp, Dept Cardiol, Mersin, Turkey -- Balli, Mehmet Mersin Toros State Hosp, Dept Cardiol, Mersin, Turkey -- Alici, Mehmet Hayri Gaziantep 25 Aralik State Hosp, Dept Cardiol, Gaziantep, Turkey -- Bozyel, Serdar Kocaeli Derince Educ & Res Hosp, Dept Cardiol, Kocaeli, Turkey -- Altun, Ibrahim -- Mert, Gurbet Ozge -- Mert, Kadir Ugur -- Sancar, Kadriye Memic Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkey -- Calik, Feyza Mersin State Hosp, Dept Cardiol, Mersin, Turkey -- Karaca, Oguz -- Gunes, Haci Murat Istanbul Medipol Univ, Fac Med, Dept Cardiol, Istanbul, Turkey -- Akay, Kadriye Kocaeli State Hosp, Dept Cardiol, Kocaeli, Turkey -- Canga, Yigit -- Bayram, Zubeyde -- Simsek, Zeki Kartal Yavuz Selim State Hosp, Dept Cardiol, Istanbul, Turkey -- Celebi, Savas TOBB ETU Hosp, Dept Cardiol, Ankara, Turkey -- Altuntas, Emine Bingol State Hosp, Dept Cardiol, Bingol, Turkey -- Bezgin, Tahir Gebze Fatih State Hosp, Dept Cardiol, Gebze, Turkey -- Aksakal, Aytekin Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- Colak, Ayse Mut State Hosp, Dept Cardiol, Mersin, Turkey -- Kaplan, Ozgur -- Gozubuyuk, Gokhan -- Dogan, Cem Malatya State Hosp, Dept Cardiol, Malatya, Turkey -- Tatlisu, Adem Sivas Numune State Hosp, Dept Cardiol, Sivas, Turkey -- Demirelli, Selami -- Sahin, Bingul Dilekci -- Ermis, Emrah Erzurum Bolge Educ & Res Hosp, Dept Cardiol, Erzurum, Turkey -- Kaya, Adnan Suruc State Hosp, Dept Cardiol, Sanliurfa, Turkey -- Rencuzogullari, Ibrahim Kafkas Univ, Fac Med, Dept Cardiol, Kars, Turkey -- Civan, Murat Istanbul Private Liv Hosp, Dept Cardiol, Istanbul, Turkey -- Batgharel, Ulaankhu Acibadem Private Hosp, Dept Cardiol, Istanbul, Turkey -- Ata, Ali Ekber Samsun Medikal Pk Hosp, Dept Cardiol, Samsun, Turkey -- Gol, Gokhan Sureyyapasa Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- Degirmencioglu, Aleks Istanbul Acibadem Univ, Fac Med, Dept Cardiol, Istanbul, Turkey -- Candan, Ozkan Usak State Hosp, Dept Cardiol, Usak, Turkey -- Celebi, Ozlem Ozcan Private Medicana Int Ankara Hosp, Dept Cardiol, Ankara, Turkey -- Yavuz, Fethi Dr Ersin Arslan State Hosp, Dept Cardiol, Gaziantep, Turkey -- Ulucan, Seref Mevlana Univ, Fac Med, Dept Cardiol, Konya, Turkey -- Arisoy, Arif Gaziosmanpasa Univ, Fac Med, Dept Cardiol, Gaziosmanpasa, Turkey -- Gokaslan, Serkan Istanbul Haydarpasa Numune Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- Pektas, Idris Mersin Univ, Fac Med, Dept Cardiol, Mersin, Turkey -- Tanindi, Asli Ufuk Univ, Fac Med, Dept Cardiol, Ufuk, Turkey -- Tekin, Kamuran Batman Bolge State Hosp, Dept Cardiol, Batman, Turkey -- Cekic, Edip Guvenc -- Basaran, Nesrin Filiz Mugla Sitki Kocman Univ, Fac Med, Dept Pharmacol, Mugla, Turkey -- Basaran, Ozcan -- Dogan, Volkan -- Biteker, Murat Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkey -- Beton, Osman Sivas Cumhuriyet Univ, Dept Cardiol, Fac Med, Sivas, Turkey -- Tekinalp, Mehmet Kahramanmaras Necip Fazil State Hosp, Dept Cardiol, Kahramanmaras, Turkey -- Aykan, Ahmet Cagri -- Kalaycioglu, Ezgi Trabzon Ahi Evren Chest Cardiovasc Surg Educ & Re, Dept Cardiol, Trabzon, Turkey -- Bolat, Ismail Fethiye State Hosp, Dept Cardiol, Fethiye, Turkey -- Tasar, Onur Elazig Educ & Res Hosp, Dept Cardiol, Elazig, Turkey -- Safak, Ozgen Burdur State Hosp, Dept Cardiol, Burdur, Turkey -- Kalcik, Macit Iskilip Atif Hoca State Hosp, Dept Cardiol, Corum, Turkey -- Yaman, Mehmet Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- Inci, Sinan Aksaray State Hosp, Dept Cardiol, Aksaray, Turkey -- Altintas, Bernas Diyarbakir Gazi Yasargil Educ & Res Hosp, Dept Cardiol, Diyarbakir, Turkey -- Kalkan, Sedat Gonen State Hosp, Dept Cardiol, Gonen, Turkey -- Kirma, Cevat Kartal Kosuyolu Heart Educ & Res Hosp, Istanbul, Turkey, BASARAN, OZCAN -- 0000-0002-6384-6455
بيانات النشر: LIPPINCOTT WILLIAMS & WILKINS
سنة النشر: 2016
المجموعة: Sivas Cumhuriyet University Institutional Repository
مصطلحات موضوعية: anticoagulation, atrial fibrillation, off-label use, over-treatment, stroke, undertreatment
الوصف: WOS: 000384041400052 ; PubMed ID: 27583892 ; This study aimed to investigate the potential misuse of novel oral anticoagulants (NOACs) and the physicians' adherence to current European guideline recommendations in real-world using a large dataset from Real-life Multicenter Survey Evaluating Stroke Prevention Strategies in Turkey (RAMSES Study).RAMSES study is a prospective, multicenter, nationwide registry (ClinicalTrials.gov identifier NCT02344901). In this subgroup analysis of RAMSES study, patients who were on NOACs were classified as appropriately treated (AT), undertreated (UT), and overtreated (OT) according to the European Society of Cardiology (ESC) guidelines. The independent predictors of UT and OT were determined by multivariate logistic regression.Of the 2086 eligible patients, 1247 (59.8%) received adequate treatment. However, off-label use was detected in 839 (40.2%) patients; 634 (30.4%) patients received UT and 205 (9.8%) received OT. Independent predictors of UT included >65 years of age, creatinine clearance 50mL/min, urban living, existing dabigatran treatment, and HAS-BLED score of <3, whereas that of OT were creatinine clearance <50mL/min, ongoing rivaroxaban treatment, and HAS-BLED score of 3.The suboptimal use of NOACs is common because of physicians' poor compliance to the guideline recommendations in patients with nonvalvular atrial fibrillation (NVAF). Older patients who were on dabigatran treatment with good renal functions and low risk of bleeding were at risk of UT, whereas patients who were on rivaroxaban treatment with renal impairment and high risk of bleeding were at risk of OT. Therefore, a greater emphasis should be given to prescribe the recommended dose for the specified patients.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 0025-7974
1536-5964
Relation: MEDICINE; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://dx.doi.org/10.1097/MD.0000000000004672; https://hdl.handle.net/20.500.12418/7236; 95; 35
DOI: 10.1097/MD.0000000000004672
الاتاحة: https://hdl.handle.net/20.500.12418/7236
https://doi.org/10.1097/MD.0000000000004672
Rights: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.AA1439A
قاعدة البيانات: BASE
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Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => WOS: 000384041400052 ; PubMed ID: 27583892 ; This study aimed to investigate the potential misuse of novel oral anticoagulants (NOACs) and the physicians&#39; adherence to current European guideline recommendations in real-world using a large dataset from Real-life Multicenter Survey Evaluating Stroke Prevention Strategies in Turkey (RAMSES Study).RAMSES study is a prospective, multicenter, nationwide registry (ClinicalTrials.gov identifier NCT02344901). In this subgroup analysis of RAMSES study, patients who were on NOACs were classified as appropriately treated (AT), undertreated (UT), and overtreated (OT) according to the European Society of Cardiology (ESC) guidelines. The independent predictors of UT and OT were determined by multivariate logistic regression.Of the 2086 eligible patients, 1247 (59.8%) received adequate treatment. However, off-label use was detected in 839 (40.2%) patients; 634 (30.4%) patients received UT and 205 (9.8%) received OT. Independent predictors of UT included &gt;65 years of age, creatinine clearance 50mL/min, urban living, existing dabigatran treatment, and HAS-BLED score of &lt;3, whereas that of OT were creatinine clearance &lt;50mL/min, ongoing rivaroxaban treatment, and HAS-BLED score of 3.The suboptimal use of NOACs is common because of physicians&#39; poor compliance to the guideline recommendations in patients with nonvalvular atrial fibrillation (NVAF). Older patients who were on dabigatran treatment with good renal functions and low risk of bleeding were at risk of UT, whereas patients who were on rivaroxaban treatment with renal impairment and high risk of bleeding were at risk of OT. Therefore, a greater emphasis should be given to prescribe the recommended dose for the specified patients. )
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Sanliurfa, Turkey -- Tekkesin, Ahmet Ilker -- Turkkan, Ceyhan -- Cakal, Beytullah Siyami Ersek Heart Educ & Res Hosp, Dept Cardiol, Istanbul, Turkey -- Cakilli, Yasin Tuzla State Hosp, Dept Cardiol, Tuzla Istanbul, Turkey -- Hamidi, Mehmet Bandirma State Hosp, Dept Cardiol, Balikesir, Turkey -- Demir, Vahit Yozgat State Hosp, Dept Cardiol, Yozgat, Turkey -- Gursoy, Mustafa Ozan Gaziemir State Hosp, Dept Cardiol, Gaziemir, Turkey -- Ozturk, Mujgan Tek -- Ayturk, Mehmet Ankara Kecioren Educ & Res Hosp, Dept Cardiol, Ankara, Turkey -- Aksan, Gokhan -- Helvaci, Fusun Sisli Hamidiye Etfal Educ & Res Hosp, Dept Cardiol, Sisli, Turkey -- Seyis, Sabri Mersin Private Dogus Hosp, Dept Cardiol, Mersin, Turkey -- Balli, Mehmet Mersin Toros State Hosp, Dept Cardiol, Mersin, Turkey -- Alici, Mehmet Hayri Gaziantep 25 Aralik State Hosp, Dept Cardiol, Gaziantep, Turkey -- Bozyel, Serdar Kocaeli Derince Educ & Res Hosp, Dept Cardiol, Kocaeli, Turkey -- Altun, Ibrahim -- Mert, Gurbet Ozge -- Mert, Kadir Ugur -- Sancar, Kadriye Memic Mugla Sitki Kocman Univ, Fac Med, Dept Cardiol, Mugla, Turkey -- Calik, Feyza Mersin State Hosp, Dept Cardiol, Mersin, Turkey -- Karaca, Oguz -- Gunes, Haci Murat Istanbul Medipol Univ, Fac Med, Dept Cardiol, Istanbul, Turkey -- Akay, Kadriye Kocaeli State Hosp, Dept Cardiol, Kocaeli, Turkey -- Canga, Yigit -- Bayram, Zubeyde -- Simsek, Zeki Kartal Yavuz Selim State Hosp, Dept Cardiol, Istanbul, Turkey -- Celebi, Savas TOBB ETU Hosp, Dept Cardiol, Ankara, Turkey -- Altuntas, Emine Bingol State Hosp, Dept Cardiol, Bingol, Turkey -- Bezgin, Tahir Gebze Fatih State Hosp, Dept Cardiol, Gebze, Turkey -- Aksakal, Aytekin Samsun Educ & Res Hosp, Dept Cardiol, Samsun, Turkey -- Colak, Ayse Mut State Hosp, Dept Cardiol, Mersin, Turkey -- Kaplan, Ozgur -- Gozubuyuk, Gokhan -- Dogan, Cem Malatya State Hosp, Dept Cardiol, Malatya, Turkey -- Tatlisu, Adem Sivas Numune State Hosp, Dept Cardiol, Sivas, Turkey -- Demirelli, Selami -- Sahin, Bingul Dilekci -- Ermis, Emrah 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