Academic Journal
Disease progression strikingly differs in research and real-world Parkinson’s populations
| العنوان: | Disease progression strikingly differs in research and real-world Parkinson’s populations |
|---|---|
| المؤلفون: | Beaulieu-Jones, Brett K., Frau, Francesca, Bozzi, Sylvie, Chandross, Karen J., Peterschmitt, M. Judith, Cohen, Caroline, Coulovrat, Catherine, Kumar, Dinesh, Kruger, Mark J., Lipnick, Scott L., Fitzsimmons, Lane, Kohane, Isaac S., Scherzer, Clemens R. |
| المساهمون: | U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke, Sanofi |
| المصدر: | npj Parkinson's Disease ; volume 10, issue 1 ; ISSN 2373-8057 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2024 |
| الوصف: | Characterization of Parkinson’s disease (PD) progression using real-world evidence could guide clinical trial design and identify subpopulations. Efforts to curate research populations, the increasing availability of real-world data, and advances in natural language processing, particularly large language models, allow for a more granular comparison of populations than previously possible. This study includes two research populations and two real-world data-derived (RWD) populations. The research populations are the Harvard Biomarkers Study (HBS, N = 935), a longitudinal biomarkers cohort study with in-person structured study visits; and Fox Insights ( N = 36,660), an online self-survey-based research study of the Michael J. Fox Foundation. Real-world cohorts are the Optum Integrated Claims-electronic health records ( N = 157,475), representing wide-scale linked medical and claims data and de-identified data from Mass General Brigham (MGB, N = 22,949), an academic hospital system. Structured, de-identified electronic health records data at MGB are supplemented using a manually validated natural language processing with a large language model to extract measurements of PD progression. Motor and cognitive progression scores change more rapidly in MGB than HBS (median survival until H&Y 3: 5.6 years vs. >10, p < 0.001; mini-mental state exam median decline 0.28 vs. 0.11, p < 0.001; and clinically recognized cognitive decline, p = 0.001). In real-world populations, patients are diagnosed more than eleven years later (RWD mean of 72.2 vs. research mean of 60.4, p < 0.001). After diagnosis, in real-world cohorts, treatment with PD medications has initiated an average of 2.3 years later (95% CI: [2.1–2.4]; p < 0.001). This study provides a detailed characterization of Parkinson’s progression in diverse populations. It delineates systemic divergences in the patient populations enrolled in research settings vs. patients in the real-world. These divergences are likely due to a combination of ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41531-024-00667-5 |
| الاتاحة: | http://dx.doi.org/10.1038/s41531-024-00667-5 https://www.nature.com/articles/s41531-024-00667-5.pdf https://www.nature.com/articles/s41531-024-00667-5 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.A85E2D36 |
| قاعدة البيانات: | BASE |
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