Academic Journal
Neuronal morphology alterations in autism and possible role of oxytocin
| العنوان: | Neuronal morphology alterations in autism and possible role of oxytocin |
|---|---|
| المؤلفون: | Falougy Hisham El, Filova Barbora, Ostatnikova Daniela, Bacova Zuzana, Bakos Jan |
| المصدر: | Endocrine Regulations, Vol 53, Iss 1, Pp 46-54 (2019) |
| بيانات النشر: | Sciendo |
| سنة النشر: | 2019 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | oxytocin, autism, brain anatomy, structural neuronal changes, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| الوصف: | Current understanding of the neuroanatomical abnormalities in autism includes gross anatomical changes in several brain areas and microstructural alterations in neuronal cells as well. There are many controversies in the interpretation of the imaging data, evaluation of volume and size of particular brain areas, and their functional translation into a broad autism phenotype. Critical questions of neuronal pathology in autism include the concept of the reversible plasticity of morphological changes, volume alterations of brain areas, and both short- and long-term consequences of adverse events present during the brain development. At the cellular level, remodeling of the actin cytoskeleton is considered as one of the critical factors associated with the autism spectrum disorders. Alterations in the composition of the neuronal cytoskeleton, in particular abnormalities in the polymerization of actin filaments and their associated proteins underlie the functional consequences in behavior resulting in symptoms and clinical correlates of autism spectrum disorder. In the present review, a special attention is devoted to the role of oxytocin in experimental models of neurodevelopmental disorders manifesting alterations in neuronal morphology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1336-0329 |
| Relation: | https://doi.org/10.2478/enr-2019-0006; https://doaj.org/toc/1336-0329; https://doaj.org/article/c64103291b504d018afbe77e9c4bbb03 |
| DOI: | 10.2478/enr-2019-0006 |
| الاتاحة: | https://doi.org/10.2478/enr-2019-0006 https://doaj.org/article/c64103291b504d018afbe77e9c4bbb03 |
| رقم الانضمام: | edsbas.A7E2D679 |
| قاعدة البيانات: | BASE |
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