Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate
| العنوان: | Real-Time Observation of “Soft” Magic-Size Clusters during Hydrolysis of the Model Metallodrug Bismuth Disalicylate |
|---|---|
| المؤلفون: | Daniel Szczerba (11496004), Davin Tan (1645231), Jean-Louis Do (1649806), Hatem M. Titi (1770970), Siham Mouhtadi (11496007), Denis Chaumont (11496010), María del Carmen Marco de Lucas (11496013), Nicolas Geoffroy (1834537), Michel Meyer (121888), Yoann Rousselin (1528294), Jessica M. Hudspeth (11496016), Valérie Schwanen (4357837), Petra Spoerk-Erdely (11496019), Ann-Christin Dippel (1370523), Oleh Ivashko (11496022), Olof Gutowski (2543221), Philipp Glaevecke (11496025), Vasilii Bazhenov (11496028), Mihails Arhangelskis (1444108), Ivan Halasz (1457194), Tomislav Friščić (1410901), Simon A. J. Kimber (10947064) |
| سنة النشر: | 2021 |
| المجموعة: | Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: | Biophysics, Biochemistry, Ecology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, yet remain mysterious, two major species, significantly higher symmetry, phase cluster structures, metallodrug bismuth subsalicylate, 9 , 38 , size ” clusters, multistep cluster growth, 3 +, size clusters, bismuth disalicylate, “ magic, sufficiently labile, state analogues, stable enough, reveals catalysis, bismol ) |
| الوصف: | Colloidal bismuth therapeutics have been used for hundreds of years, yet remain mysterious. Here we report an X-ray pair distribution function (PDF) study of the solvolysis of bismuth disalicylate, a model for the metallodrug bismuth subsalicylate (Pepto-Bismol). This reveals catalysis by traces of water, followed by multistep cluster growth. The ratio of the two major species, {Bi 9 O 7 } and {Bi 38 O 44 }, depends on exposure to air, time, and the solvent. The solution-phase cluster structures are of significantly higher symmetry in comparison to solid-state analogues, with reduced off-center Bi 3+ displacements. This explains why such “magic-size” clusters can be both stable enough to crystallize and sufficiently labile for further growth. |
| نوع الوثيقة: | dataset |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/dataset/Real-Time_Observation_of_Soft_Magic-Size_Clusters_during_Hydrolysis_of_the_Model_Metallodrug_Bismuth_Disalicylate/16695313 |
| DOI: | 10.1021/jacs.1c07186.s002 |
| الاتاحة: | https://doi.org/10.1021/jacs.1c07186.s002 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.A1031880 |
| قاعدة البيانات: | BASE |
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