Academic Journal
The statistical approach in trial-based economic evaluations matters: get your statistics together!
| العنوان: | The statistical approach in trial-based economic evaluations matters: get your statistics together! |
|---|---|
| المؤلفون: | Mutubuki, Elizabeth N., el Alili, Mohamed, Bosmans, Judith E., Oosterhuis, Teddy, J. Snoek, Frank, Ostelo, Raymond W. J. G., van Tulder, Maurits W., van Dongen, Johanna M. |
| المصدر: | Mutubuki , E N , el Alili , M , Bosmans , J E , Oosterhuis , T , J. Snoek , F , Ostelo , R W J G , van Tulder , M W & van Dongen , J M 2021 , ' The statistical approach in trial-based economic evaluations matters: get your statistics together! ' , BMC Health Services Research , vol. 21 , no. 1 , 475 . https://doi.org/10.1186/s12913-021-06513-1 |
| سنة النشر: | 2021 |
| الوصف: | Background: Baseline imbalances, skewed costs, the correlation between costs and effects, and missing data are statistical challenges that are often not adequately accounted for in the analysis of cost-effectiveness data. This study aims to illustrate the impact of accounting for these statistical challenges in trial-based economic evaluations. Methods: Data from two trial-based economic evaluations, the REALISE and HypoAware studies, were used. In total, 14 full cost-effectiveness analyses were performed per study, in which the four statistical challenges in trial-based economic evaluations were taken into account step-by-step. Statistical approaches were compared in terms of the resulting cost and effect differences, ICERs, and probabilities of cost-effectiveness. Results: In the REALISE study and HypoAware study, the ICER ranged from 636,744€/QALY and 90,989€/QALY when ignoring all statistical challenges to − 7502€/QALY and 46,592€/QALY when accounting for all statistical challenges, respectively. The probabilities of the intervention being cost-effective at 0€/ QALY gained were 0.67 and 0.59 when ignoring all statistical challenges, and 0.54 and 0.27 when all of the statistical challenges were taken into account for the REALISE study and HypoAware study, respectively. Conclusions: Not accounting for baseline imbalances, skewed costs, correlated costs and effects, and missing data in trial-based economic evaluations may notably impact results. Therefore, when conducting trial-based economic evaluations, it is important to align the statistical approach with the identified statistical challenges in cost-effectiveness data. To facilitate researchers in handling statistical challenges in trial-based economic evaluations, software code is provided. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1186/s12913-021-06513-1 |
| الاتاحة: | https://research.vumc.nl/en/publications/0487f173-6c47-4de3-9e02-8b7e42ba4f23 https://doi.org/10.1186/s12913-021-06513-1 http://www.scopus.com/inward/record.url?scp=85106057833&partnerID=8YFLogxK |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.9B9FC35E |
| قاعدة البيانات: | BASE |
كن أول من يترك تعليقا!