Academic Journal
Cracking the immune fingerprint of metal-organic frameworks
| العنوان: | Cracking the immune fingerprint of metal-organic frameworks |
|---|---|
| المؤلفون: | Hidalgo, Tania, Simón-Vázquez, Rosana, González-Fernández, África, Horcajada, Patricia |
| المساهمون: | Institut Lavoisier de Versailles (ILV), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Instituto IMDEA Energia, Universidade de Vigo, 2018-T2/IND-11407, GRC-ED431C 2020/02, RED2018-102471-T, ANR-11-IDEX-0003-02, 2014, H2020 Marie Skłodowska-Curie Actions, MSCA: 897678, Centre National de la Recherche Scientifique, CNRS, Horizon 2020, This work was partially supported by the Labex NanoSaclay nancial support for the MSc studies (ANR-11-IDEX-0003-02) together with the CNRS, IMDEA Energy and Xunta de Galicia (GRC-ED431C 2020/02) funding. T. H. and P. H. acknowledge the Regional Madrid Founding (Talento 2018 Modality 2, (2018-T2/IND-11407), the Multifunctional Metallodrugs in Diagnosis and Therapy Network (MICIU, RED2018-102471-T) and the European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement No 897678. P. H. acknowledges the Spanish Ramón y Cajal Programme (grant agreement no. 2014 to 16823)., ANR-11-IDEX-0003,IPS,Idex Paris-Saclay(2011) |
| المصدر: | ISSN: 2041-6520. |
| بيانات النشر: | HAL CCSD The Royal Society of Chemistry |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | [CHIM.MATE]Chemical Sciences/Material chemistry, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, [SDV.IMM.IA]Life Sciences [q-bio]/Immunology/Adaptive immunology |
| الوصف: | International audience ; The human body is in a never-ending chess game against pathogens. When the immune system, our natural defence tool, is weakened, these organisms are able to escape, overcoming the body's contingency plan, which results in the body going into a pathological state. To overcome this checkmate status, emerging nanomedicines have been successfully employed as one of the best tactics for boosting the immune response, manipulating the body's defence tools for the specific recognition/elimination of pathological cells via the active ingredient delivery. However, the vast majority of these drug-delivery systems (DDS) are considered to be exclusively passive vehicles, with nanoscale metal-organic frameworks (nanoMOFs) attracting a great deal of attention due to their versatility and ability to carry and deliver exceptional drug payloads and to modulate their biological bypass. Nonetheless, their intrinsic immunogenicity character has been never addressed. Considering the immense possibilities that nanoMOFs offer as a treatment platform, the present study aimed to unveil the immunological fingerprint of MOFs, including an in-deep evaluation of the cellular oxidation balance, the inflammation and recruitment of immune cells and the precise Th1/Th2 cytokine profile that is triggered. This study aims to gain insights that will make more feasible the design of customized immune-active MOF nanoplatforms according to targeted diseases, as the next ace up immune system sleeve. This journal is |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03579496; https://hal.science/hal-03579496; https://hal.science/hal-03579496/document; https://hal.science/hal-03579496/file/SC-013-D1SC04112F.pdf; PUBMEDCENTRAL: PMC8790785 |
| DOI: | 10.1039/d1sc04112f |
| الاتاحة: | https://hal.science/hal-03579496 https://hal.science/hal-03579496/document https://hal.science/hal-03579496/file/SC-013-D1SC04112F.pdf https://doi.org/10.1039/d1sc04112f |
| Rights: | http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.9A35D250 |
| قاعدة البيانات: | BASE |
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