Academic Journal
Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men.
| العنوان: | Exercise-induced lipid mobilization in subcutaneous adipose tissue is mainly related to natriuretic peptides in overweight men. |
|---|---|
| المؤلفون: | Moro, Cédric, Pillard, Fabien, de Glisezinski, Isabelle, Klimcáková, Eva, Crampes, Francois, Thalamas, Claire, Harant, Isabelle, Marques, Marie-Adeline, Lafontan, Max, Berlan, Michel |
| المساهمون: | Unité de recherche sur les obésités, IFR 31 Louis Bugnard (IFR 31), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Pharmacologie Clinique CHU Toulouse, Pôle Santé publique et médecine publique CHU Toulouse, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service d'exploration de la fonction respiratoire et de médecine du sport, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut de médecine moléculaire de Rangueil (I2MR), Université de Toulouse (UT)-Université de Toulouse (UT)- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service Endocrinologie, maladies métaboliques et nutrition CHU Toulouse, Pôle Cardiovasculaire et Métabolique CHU Toulouse, Laboratoire des Adaptations de l'Organisme à l'Exercice Musculaire, Institut de minéralogie et de physique des milieux condensés (IMPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Diderot - Paris 7 (UPD7)-Institut de Physique du Globe de Paris (IPG Paris)-Centre National de la Recherche Scientifique (CNRS), Franco-czech Laboratory for clinical research on obesity, Institut National de la Santé et de la Recherche Médicale (INSERM)-Univerzita Karlova Praha, Česká republika = Charles University Prague, Czech Republic (UK), Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie de l'adipocyte, physiologie du tissu adipeux et obésités, Université de Toulouse (UT)-Université de Toulouse (UT)-Institut Louis Bugnard-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Pharmacocinétique et de Toxicologie CHU Toulouse, Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie CHU Toulouse |
| المصدر: | ISSN: 0193-1849. |
| بيانات النشر: | HAL CCSD American Physiological Society |
| سنة النشر: | 2008 |
| المجموعة: | Université Toulouse III - Paul Sabatier: HAL-UPS |
| مصطلحات موضوعية: | MESH: Adrenergic alpha-Antagonists, MESH: Adrenergic beta-Antagonists, MESH: Thiophenes, MESH: Adult, MESH: Atrial Natriuretic Factor, MESH: Blood Glucose, MESH: Cross-Over Studies, MESH: Dose-Response Relationship, Drug, MESH: Double-Blind Method, MESH: Exercise, MESH: Glycerol, MESH: Humans, MESH: Insulin, MESH: Lipid Mobilization, MESH: Male, MESH: Overweight, MESH: Phentolamine, MESH: Propanolamines, MESH: Subcutaneous Fat, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| الوصف: | International audience ; Involvement of sympathetic nervous system and natriuretic peptides in the control of exercise-induced lipid mobilization was compared in overweight and lean men. Lipid mobilization was determined using local microdialysis during exercise. Subjects performed 35-min exercise bouts at 60% of their maximal oxygen consumption under placebo or after oral tertatolol [a beta-adrenergic receptor (AR) antagonist]. Under placebo, exercise increased dialysate glycerol concentration (DGC) in both groups. Phentolamine (alpha-AR antagonist) potentiated exercise-induced lipolysis in overweight but not in lean subjects; the alpha(2)-antilipolytic effect was only functional in overweight men. After tertatolol administration, the DGC increased similarly during exercise no matter which was used probe in both groups. Compared with the control probe under placebo, lipolysis was reduced in lean but not in overweight men treated with the beta-AR blocker. Tertatolol reduced plasma nonesterified fatty acids and insulin concentration in both groups at rest. Under placebo or tertatolol, the exercise-induced changes in plasma nonesterified fatty acids, glycerol, and insulin concentrations were similar in both groups. Exercise promoted a higher increase in catecholamine and ANP plasma levels after tertatolol administration. In conclusion, the major finding of our study is that in overweight men, in addition to an increased alpha(2)-antilipolytic effect, the lipid mobilization in subcutaneous adipose tissue that persists during exercise under beta-blockade is not dependent on catecholamine action. On the basis of correlation findings, it seems to be related to a concomitant exercise-induced rise in plasma ANP when exercise is performed under tertatolol intake and a decrease in plasma insulin. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/18559985; hal-00355326; https://hal.science/hal-00355326; PUBMED: 18559985 |
| DOI: | 10.1152/ajpendo.90227.2008 |
| الاتاحة: | https://hal.science/hal-00355326 https://doi.org/10.1152/ajpendo.90227.2008 |
| رقم الانضمام: | edsbas.975F3D0B |
| قاعدة البيانات: | BASE |
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