Academic Journal
Symptomatic malaria enhances protection from reinfection with homologous Plasmodium falciparum parasites.
| العنوان: | Symptomatic malaria enhances protection from reinfection with homologous Plasmodium falciparum parasites. |
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| المؤلفون: | Christine F Markwalter, Jens E V Petersen, Erica E Zeno, Kelsey M Sumner, Elizabeth Freedman, Judith N Mangeni, Lucy Abel, Andrew A Obala, Wendy Prudhomme-O'Meara, Steve M Taylor |
| المصدر: | PLoS Pathogens, Vol 19, Iss 6, p e1011442 (2023) |
| بيانات النشر: | Public Library of Science (PLoS) |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5 |
| الوصف: | A signature remains elusive of naturally-acquired immunity against Plasmodium falciparum. We identified P. falciparum in a 14-month cohort of 239 people in Kenya, genotyped at immunogenic parasite targets expressed in the pre-erythrocytic (circumsporozoite protein, CSP) and blood (apical membrane antigen 1, AMA-1) stages, and classified into epitope type based on variants in the DV10, Th2R, and Th3R epitopes in CSP and the c1L region of AMA-1. Compared to asymptomatic index infections, symptomatic malaria was associated with reduced reinfection by parasites bearing homologous CSP-Th2R (adjusted hazard ratio [aHR]:0.63; 95% CI:0.45-0.89; p = 0.008) CSP-Th3R (aHR:0.71; 95% CI:0.52-0.97; p = 0.033), and AMA-1 c1L (aHR:0.63; 95% CI:0.43-0.94; p = 0.022) epitope types. The association of symptomatic malaria with reduced hazard of homologous reinfection was strongest for rare epitope types. Symptomatic malaria provides more durable protection against reinfection with parasites bearing homologous epitope types. The phenotype represents a legible molecular epidemiologic signature of naturally-acquired immunity by which to identify new antigen targets. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1553-7366 1553-7374 |
| Relation: | https://doi.org/10.1371/journal.ppat.1011442; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374; https://doaj.org/article/467a27cdd76a4227802c97af5ea64c80 |
| DOI: | 10.1371/journal.ppat.1011442 |
| الاتاحة: | https://doi.org/10.1371/journal.ppat.1011442 https://doaj.org/article/467a27cdd76a4227802c97af5ea64c80 |
| رقم الانضمام: | edsbas.9487ECE0 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15537366 15537374 |
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| DOI: | 10.1371/journal.ppat.1011442 |