Academic Journal
Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma
| العنوان: | Simple parameters predicting extrahepatic recurrence after curative hepatectomy for hepatocellular carcinoma |
|---|---|
| المؤلفون: | Yoon, Jae Hyun, Lee, Won Jae, Kim, Sun Min, Kim, Kwang Tack, Cho, Sung Bum, Kim, Hee Joon, Ko, Yang Seok, Kook, Hyun Yi, Jun, Chung Hwan, Choi, Sung Kyu, Kim, Ban Seok, Cho, Seo Yeon, You, Hye-Su, Lee, Yohan, Son, Seyeong |
| المساهمون: | Chonnam National University Hospital Biomedical Research Institute |
| المصدر: | Scientific Reports ; volume 11, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2021 |
| الوصف: | Extrahepatic recurrence (EHR) after curative hepatectomy for hepatocellular carcinoma (HCC) is associated with a poor prognosis. We investigated the features of EHR and identified its predictive factors. This retrospective study included 398 treatment-naive patients who underwent curative hepatectomy for HCC at two tertiary hospitals. Multivariate Cox-regression analysis was performed to identify the variables associated with EHR. EHR was diagnosed in 94 patients (23.6%) over a median follow-up period of 5.92 years, most commonly in the lungs (42.6%). The 5-/10-year cumulative rates of HCC recurrence and EHR were 63.0%/75.6% and 18.1%/35.0%, respectively. The median time to EHR was 2.06 years. Intrahepatic HCC recurrence was not observed in 38.3% of patients on EHR diagnosis. On multivariate analysis, pathologic modified Union for International Cancer Control stage (III, IVa), surgical margin involvement, tumor necrosis, sum of tumor size > 7 cm, and macrovascular invasion were predictive factors of EHR. Four risk levels and their respective EHR rates were defined as follows: very low risk, 1-/5-year, 3.1%/11.6%; low risk, 1-/5-year, 12.0%/27.7%; intermediate risk, 1-/5-year, 36.3%/60.9%; and high risk, 1-year, 100.0%. Our predictive model clarifies the clinical course of EHR and could improve the follow-up strategy to improve outcomes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-021-92503-6 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-021-92503-6 https://www.nature.com/articles/s41598-021-92503-6.pdf https://www.nature.com/articles/s41598-021-92503-6 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.93F080B8 |
| قاعدة البيانات: | BASE |
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