Academic Journal
Differential effects of 670 and 830 nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury
| العنوان: | Differential effects of 670 and 830 nm red near infrared irradiation therapy: a comparative study of optic nerve injury, retinal degeneration, traumatic brain and spinal cord injury |
|---|---|
| المؤلفون: | Giacci, M., Wheeler, L., Lovett, S., Dishington, E., Majda, B., Bartlett, C., Thornton, E., Harford-Wright, E., Leonard, A., Vink, R., Harvey, A., Provis, J., Dunlop, S., Hart, N., Hodgetts, S., Natoli, R., Van Den Heuvel, C., Fitzgerald, M. |
| المساهمون: | Borlongan, C. |
| المصدر: | http://dx.doi.org/10.1371/journal.pone.0104565. |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2014 |
| المجموعة: | The University of Adelaide: Digital Library |
| مصطلحات موضوعية: | Brain, Spinal Cord, Optic Nerve, Retina, Animals, Rats, Sprague-Dawley, Brain Injuries, Spinal Cord Injuries, Optic Nerve Injuries, Retinal Degeneration, Infrared Rays, Female, Male |
| الوصف: | Red/near-infrared irradiation therapy (R/NIR-IT) delivered by laser or light-emitting diode (LED) has improved functional outcomes in a range of CNS injuries. However, translation of R/NIR-IT to the clinic for treatment of neurotrauma has been hampered by lack of comparative information regarding the degree of penetration of the delivered irradiation to the injury site and the optimal treatment parameters for different CNS injuries. We compared the treatment efficacy of R/NIR-IT at 670 nm and 830 nm, provided by narrow-band LED arrays adjusted to produce equal irradiance, in four in vivo rat models of CNS injury: partial optic nerve transection, light-induced retinal degeneration, traumatic brain injury (TBI) and spinal cord injury (SCI). The number of photons of 670 nm or 830 nm light reaching the SCI injury site was 6.6% and 11.3% of emitted light respectively. Treatment of rats with 670 nm R/NIR-IT following partial optic nerve transection significantly increased the number of visual responses at 7 days after injury (P ≤ 0.05); 830 nm R/NIR-IT was partially effective. 670 nm R/NIR-IT also significantly reduced reactive species and both 670 nm and 830 nm R/NIR-IT reduced hydroxynonenal immunoreactivity (P ≤ 0.05) in this model. Pre-treatment of light-induced retinal degeneration with 670 nm R/NIR-IT significantly reduced the number of Tunel+ cells and 8-hydroxyguanosine immunoreactivity (P ≤ 0.05); outcomes in 830 nm R/NIR-IT treated animals were not significantly different to controls. Treatment of fluid-percussion TBI with 670 nm or 830 nm R/NIR-IT did not result in improvements in motor or sensory function or lesion size at 7 days (P>0.05). Similarly, treatment of contusive SCI with 670 nm or 830 nm R/NIR-IT did not result in significant improvements in functional recovery or reduced cyst size at 28 days (P>0.05). Outcomes from this comparative study indicate that it will be necessary to optimise delivery devices, wavelength, intensity and duration of R/NIR-IT individually for different CNS injury ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | PLoS One, 2014; 9(8):e104565-1-e104565-15; http://hdl.handle.net/2440/94985; Leonard, A. [0000-0002-9430-3314]; Vink, R. [0000-0002-4885-0667]; Van Den Heuvel, C. [0000-0003-0664-8935] |
| DOI: | 10.1371/journal.pone.0104565 |
| الاتاحة: | http://hdl.handle.net/2440/94985 https://doi.org/10.1371/journal.pone.0104565 |
| Rights: | © 2014 Giacci et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| رقم الانضمام: | edsbas.93E8629D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 19326203 |
|---|---|
| DOI: | 10.1371/journal.pone.0104565 |