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LLPS disrupting agent effects on KSHV transcription and LANA binding.

التفاصيل البيبلوغرافية
العنوان: LLPS disrupting agent effects on KSHV transcription and LANA binding.
المؤلفون: Olga Vladimirova (6265013), Alessandra De Leo (3685876), Zhong Deng (56110), Andreas Wiedmer (56111), James Hayden (222052), Paul M. Lieberman (9167583)
سنة النشر: 2021
المجموعة: Smithsonian Institution: Digital Repository
مصطلحات موضوعية: Biochemistry, Cancer, Infectious Diseases, Virology, Biological Sciences not elsewhere classified, KSHV genome dynamics, reactivation Liquid-liquid phase se., KSHV DNA, Phase separation, PML foci, LLPS disruption, DAXX colocalizes, DAXX redistribution, LANA-dependent KSHV chromosome conf., form LANA-associated replication co., Latency-Associated Nuclear Antigen, LANA-NB formation, lytic reactivation, KSHV genome conformation, KSHV lytic reactivation, LANA-associated lytic replication c.
الوصف: A . Immunoblotting of LANA, RAD21, PARP1, Coilin, DAXX and actin in BCBL1 cells exposed to 3.5% 1,6-Hexanediol for the indicated times. B . RT-qPCR for lytic transcripts ORF50, PAN and latent transcript LANA relative to cellular actin in BCBL1 cells treated as in panel A. The data are expressed as fold change of the treated versus untreated cells. C . BCBL1 and iSLK RFP-LANA cells treated for 1 hr with 3.5% 1,6-Hexanediol were assayed by ChIP for LANA or IgG. ChIP-qPCR primer positions indicated on x-axis are relative to KSHV genome. GAPDH primers were used as internal control. * p value < 0.05, two-tailed t-test.
نوع الوثيقة: still image
اللغة: unknown
Relation: https://figshare.com/articles/figure/LLPS_disrupting_agent_effects_on_KSHV_transcription_and_LANA_binding_/13618738
DOI: 10.1371/journal.ppat.1009231.g003
الاتاحة: https://doi.org/10.1371/journal.ppat.1009231.g003
Rights: CC BY 4.0
رقم الانضمام: edsbas.93CCB7ED
قاعدة البيانات: BASE
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