Academic Journal
Telomere Healing Following DNA polymerase Arrest Induced Breakages is likely the Main Mechanism Generating Chromosome 4p Terminal Deletions
| العنوان: | Telomere Healing Following DNA polymerase Arrest Induced Breakages is likely the Main Mechanism Generating Chromosome 4p Terminal Deletions |
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| المؤلفون: | Hannes, Femke, Van Houdt, Jeroen, Quarrell, Oliver W., Poot, Martin, Hochstenbach, Ron, Fryns, Jean-Pierre, Vermeesch, Joris Robert |
| المساهمون: | Center for Human Genetics, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Sheffield Children's NHS Foundation Trust, University Medical Center Utrecht, Centre of Human Genetics, University Hospitals Leuven Leuven |
| المصدر: | ISSN: 1059-7794. |
| بيانات النشر: | HAL CCSD Wiley |
| سنة النشر: | 2010 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | Life Sciences |
| الوصف: | International audience ; Constitutional developmental disorders are frequently caused by terminal chromosomal deletions. The mechanisms and/or architectural features that might underlie those chromosome breakages remain largely unexplored. Since telomeres are the vital DNA protein complexes stabilizing linear chromosomes against chromosome degradation, fusion and incomplete replication, those terminal deleted chromosomes acquired new telomeres either by telomere healing or by telomere capture. To unravel the mechanisms leading to chromosomal breakage and healing, we sequenced nine chromosome 4p terminal deletion boundaries. A computational analysis of the breakpoint flanking region, including 12 previously published pure terminal breakage sites, was performed in order to identify architectural features that might be involved in this process. All terminal 4p truncations were likely stabilized by telomerase mediated telomere healing. In the majority of breakpoints multiple genetic elements have a potential to induce secondary structures and an enrichment in replication stalling site motifs were identified. These findings suggest DNA replication stalling induced chromosome breakage during early development is the first mechanistic step leading towards terminal deletion syndromes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-00593433; https://hal.archives-ouvertes.fr/hal-00593433; https://hal.archives-ouvertes.fr/hal-00593433/document; https://hal.archives-ouvertes.fr/hal-00593433/file/PEER_stage2_10.1002%252Fhumu.21368.pdf |
| DOI: | 10.1002/humu.21368 |
| الاتاحة: | https://hal.archives-ouvertes.fr/hal-00593433 https://hal.archives-ouvertes.fr/hal-00593433/document https://hal.archives-ouvertes.fr/hal-00593433/file/PEER_stage2_10.1002%252Fhumu.21368.pdf https://doi.org/10.1002/humu.21368 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.93B38DBF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/humu.21368 |
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