Academic Journal
Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities
| العنوان: | Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities |
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| المؤلفون: | Zhang, W, Kedzierski, L, Chua, BY, Mayo, M, Lonzi, C, Rigas, V, Middleton, BF, McQuilten, HA, Rowntree, LC, Allen, LF, Purcell, RA, Tan, H-X, Petersen, J, Chaurasia, P, Mordant, F, Pogorelyy, MV, Minervina, AA, Crawford, JC, Perkins, GB, Zhang, E, Gras, S, Clemens, EB, Juno, JA, Audsley, J, Khoury, DS, Holmes, NE, Thevarajan, I, Subbarao, K, Krammer, F, Cheng, AC, Davenport, MP, Grubor-Bauk, B, Coates, PT, Christensen, B, Thomas, PG, Wheatley, AK, Kent, SJ, Rossjohn, J, Chung, AW, Boffa, J, Miller, A, Lynar, S, Nelson, J, Nguyen, THO, Davies, J, Kedzierska, K |
| بيانات النشر: | NATURE PORTFOLIO |
| سنة النشر: | 2023 |
| المجموعة: | The University of Melbourne: Digital Repository |
| الوصف: | High-risk groups, including Indigenous people, are at risk of severe COVID-19. Here we found that Australian First Nations peoples elicit effective immune responses to COVID-19 BNT162b2 vaccination, including neutralizing antibodies, receptor-binding domain (RBD) antibodies, SARS-CoV-2 spike-specific B cells, and CD4+ and CD8+ T cells. In First Nations participants, RBD IgG antibody titers were correlated with body mass index and negatively correlated with age. Reduced RBD antibodies, spike-specific B cells and follicular helper T cells were found in vaccinated participants with chronic conditions (diabetes, renal disease) and were strongly associated with altered glycosylation of IgG and increased interleukin-18 levels in the plasma. These immune perturbations were also found in non-Indigenous people with comorbidities, indicating that they were related to comorbidities rather than ethnicity. However, our study is of a great importance to First Nations peoples who have disproportionate rates of chronic comorbidities and provides evidence of robust immune responses after COVID-19 vaccination in Indigenous people. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1529-2908 1529-2916 |
| Relation: | NHMRC/1116530; NHMRC/1136322; NHMRC/1173871; NHMRC/1194036; pii: 10.1038/s41590-023-01508-y; Zhang, W., Kedzierski, L., Chua, B. Y., Mayo, M., Lonzi, C., Rigas, V., Middleton, B. F., McQuilten, H. A., Rowntree, L. C., Allen, L. F., Purcell, R. A., Tan, H. -X., Petersen, J., Chaurasia, P., Mordant, F., Pogorelyy, M. V., Minervina, A. A., Crawford, J. C., Perkins, G. B. ,. Kedzierska, K. (2023). Robust and prototypical immune responses toward COVID-19 vaccine in First Nations peoples are impacted by comorbidities. NATURE IMMUNOLOGY, 24 (6), https://doi.org/10.1038/s41590-023-01508-y.; http://hdl.handle.net/11343/332997 |
| الاتاحة: | http://hdl.handle.net/11343/332997 |
| Rights: | CC BY ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.8E273D2 |
| قاعدة البيانات: | BASE |
| تدمد: | 15292908 15292916 |
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