Academic Journal
Tailoring the Photoelectrochemical Activity of Hexametaphosphate-Capped CdS Quantum Dots by Ca 2+ -Triggered Surface Charge Regulation: A New Signaling Strategy for Sensitive Immunoassay
| العنوان: | Tailoring the Photoelectrochemical Activity of Hexametaphosphate-Capped CdS Quantum Dots by Ca 2+ -Triggered Surface Charge Regulation: A New Signaling Strategy for Sensitive Immunoassay |
|---|---|
| المؤلفون: | Yanqun Chen (7391732), Min Zhou (173135), Jinhua Yang (2019088), Yueming Tan (1400500), Wenfang Deng (1765939), Qingji Xie (1400497) |
| سنة النشر: | 1753 |
| المجموعة: | Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: | Biophysics, Microbiology, Cell Biology, Molecular Biology, Physiology, Pharmacology, Immunology, Cancer, Computational Biology, Space Science, Physical Sciences not elsewhere classified, novel “ signal, 1 pg ml, negative surface charges, efficient signaling strategies, 3 , 2 , linear detection range, 2 +, new signaling strategy, hmp qds decrease, sensitive pec immunoassay, efficient strategy, sensitive detection, surface charge, sensitive immunoassay, detection limit, significantly boosted, photoelectric conversion, photoactive materials |
| الوصف: | The development of efficient signaling strategies is highly important for photoelectrochemical (PEC) immunoassay. We report here a new and efficient strategy for sensitive PEC immunoassay by tailoring the electrostatic interaction between the photoactive material and the electron donor. The photoelectric conversion of hexametaphosphate (HMP)-capped CdS quantum dots (QDs) in Na 2 SO 3 solution is significantly boosted after Ca 2+ incubation. The negative surface charges on CdS@HMP QDs decrease because of the complexation reaction between HMP and Ca 2+ , and the electrostatic repulsion between CdS@HMP QDs and electron donor (SO 3 2– ) becomes weak accordingly, leading to an improved electron–hole separation efficiency. Inspired by the PEC response of CdS@HMP QDs to Ca 2+ , a novel “signal-on” PEC immunoassay platform is established by employing CaCO 3 nanoparticles as labels. By regulating the surface charge of CdS@HMP QDs with in situ-generated Ca 2+ from CaCO 3 labels, sensitive detection of the carcinoembryonic antigen (CEA) is achieved. The linear detection range is 0.005–50 ng mL –1 and the detection limit is 1 pg mL –1 for CEA detection. Our work not only provides a facile route to tailor the photoelectric conversion but also lays the foundation for sensitive PEC immunoassay by simply regulating the surface charge of photoactive materials. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Tailoring_the_Photoelectrochemical_Activity_of_Hexametaphosphate-Capped_CdS_Quantum_Dots_by_Ca_sup_2_sup_-Triggered_Surface_Charge_Regulation_A_New_Signaling_Strategy_for_Sensitive_Immunoassay/16734756 |
| DOI: | 10.1021/acs.analchem.1c02284.s001 |
| الاتاحة: | https://doi.org/10.1021/acs.analchem.1c02284.s001 |
| Rights: | CC BY-NC 4.0 |
| رقم الانضمام: | edsbas.8B5C2DB6 |
| قاعدة البيانات: | BASE |
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