Academic Journal
Primary Pulmonary Myxoid Sarcoma and Myxoid Angiomatoid Fibrous Histiocytoma ; A Unifying Continuum With Shared and Distinct Features
| العنوان: | Primary Pulmonary Myxoid Sarcoma and Myxoid Angiomatoid Fibrous Histiocytoma ; A Unifying Continuum With Shared and Distinct Features |
|---|---|
| المؤلفون: | Gui, Hongxing, Sussman, Robyn T., Jian, Bo, Brooks, John S., Zhang, Paul J.L. |
| المصدر: | American Journal of Surgical Pathology ; volume 44, issue 11, page 1535-1540 ; ISSN 0147-5185 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: | 2020 |
| الوصف: | Primary pulmonary myxoid sarcoma (PPMS) is a recently reported, exceedingly rare low-grade lung neoplasm characterized by reticular/lace-like growth of spindle to epithelioid cells embedded in an abundant myxoid matrix. Morphologically, it overlaps with a myxoid variant of angiomatoid fibrous histiocytoma (AFH) of the soft tissue. Genetically, they were both reported to harbor EWSR1-CREB1 fusion, while EWSR1-ATF1 has only been reported in AFH thus far. We report a case of primary pulmonary low-grade myxoid spindle cell tumor with morphologic and immunohistochemical features of PPMS but with an EWSR1-ATF1 fusion gene. In addition, we also encountered a case of endobronchial AFH with EWSR1-CREB1 translocation but also focal morphologic features of PPMS. These findings provide new evidence supporting the concept that PPMS and a myxoid variant of AFH represent a continuum with overlapping histologic, immunohistochemical, and genetic features. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1097/pas.0000000000001548 |
| DOI: | 10.1097/PAS.0000000000001548 |
| الاتاحة: | http://dx.doi.org/10.1097/pas.0000000000001548 https://journals.lww.com/10.1097/PAS.0000000000001548 |
| رقم الانضمام: | edsbas.8983009 |
| قاعدة البيانات: | BASE |
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