Academic Journal
أعرض في EDS

Identification of multiple transcription factor genes potentially involved in the development of electrosensory versus mechanosensory lateral line organs

التفاصيل البيبلوغرافية
العنوان: Identification of multiple transcription factor genes potentially involved in the development of electrosensory versus mechanosensory lateral line organs
المؤلفون: Minařík, Martin, Modrell, Melinda S, Gillis, J Andrew, Campbell, Alexander S, Fuller, Isobel, Lyne, Rachel, Micklem, Gos, Gela, David, Pšenička, Martin, Baker, Clare VH
بيانات النشر: Frontiers Media SA
//doi.org/10.3389/fcell.2024.1327924
Frontiers in Cell and Developmental Biology
سنة النشر: 2024
المجموعة: Apollo - University of Cambridge Repository
مصطلحات موضوعية: mechanosensory, sterlet, neuromast, paddlefish, lateral line organs, sturgeon, electrosensory, ampullary organ
الوصف: Peer reviewed: True ; Acknowledgements: Thanks to Marek Rodina and Martin Kahanec for their help with sterlet spawns, and Michaela Vazačová for her help with embryo incubation and fixation. Thanks to Tatjana Piotrowski and her lab at the Stowers Institute for Medical Research (Kansas City, MO, United States) and Steve and Pete Kahrs and the Kahrs family (Osage Catfisheries, Inc.) for hosting MSM during paddlefish spawning seasons. Thanks to Christine Hirschberger and Rolf Ericsson for their help with some of the in situ hybridization rounds. Thanks to Nathanael Walker-Hale for advice on phylogenetic analysis. ; In electroreceptive jawed vertebrates, embryonic lateral line placodes give rise to electrosensory ampullary organs as well as mechanosensory neuromasts. Previous reports of shared gene expression suggest that conserved mechanisms underlie electroreceptor and mechanosensory hair cell development and that electroreceptors evolved as a transcriptionally related “sister cell type” to hair cells. We previously identified only one transcription factor gene, Neurod4, as ampullary organ-restricted in the developing lateral line system of a chondrostean ray-finned fish, the Mississippi paddlefish (Polyodon spathula). The other 16 transcription factor genes we previously validated in paddlefish were expressed in both ampullary organs and neuromasts. Here, we used our published lateral line organ-enriched gene-set (arising from differential bulk RNA-seq in late-larval paddlefish), together with a candidate gene approach, to identify 25 transcription factor genes expressed in the developing lateral line system of a more experimentally tractable chondrostean, the sterlet (Acipenser ruthenus, a small sturgeon), and/or that of paddlefish. Thirteen are expressed in both ampullary organs and neuromasts, consistent with conservation of molecular mechanisms. Seven are electrosensory-restricted ...
نوع الوثيقة: article in journal/newspaper
وصف الملف: text/xml; application/zip; application/pdf
اللغة: English
Relation: https://www.repository.cam.ac.uk/handle/1810/366516
الاتاحة: https://www.repository.cam.ac.uk/handle/1810/366516
Rights: Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/
رقم الانضمام: edsbas.87A1458A
قاعدة البيانات: BASE
الوصف
الوصف غير متاح.