Academic Journal
Effect of tadalafil on penile nitric oxide synthase and corporal smooth muscle in rats under dutasteride treatment
| العنوان: | Effect of tadalafil on penile nitric oxide synthase and corporal smooth muscle in rats under dutasteride treatment |
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| المؤلفون: | Gül, Abdullah, Altınay, Serdar, Kabasakal, Levent, Yavuz, Abdulmecit, Semerciöz, Atilla, Şerefoğlu, Ege Can |
| المساهمون: | Tıp Fakültesi |
| بيانات النشر: | Taylor & Francis |
| سنة النشر: | 2020 |
| المجموعة: | Biruni University Institutional Repository (DSpace@Biruni) |
| مصطلحات موضوعية: | Dutasteride, Erectile Dysfunction, Tadalafil, Nitric Oxide Synthase, Rat |
| الوصف: | Aim: To investigate the effect of tadalafil in rats administered with daily dutasteride. Methods: Twenty-four Sprague–Dawley male rats were allocated to three groups as control (group C), dutasteride (group D) and dutasteride plus tadalafil (group D þ T). After a month of treatment, serum samples were obtained from rats to measure dihydrotestosterone and total testosterone. Nitric oxide (NO) synthase (NOS) immunoreactivity and levels of NOS enzyme isoforms, NO and cyclic guanosine monophosphate (cGMP) were evaluated in the harvested penile tissues. Also, corporal smooth muscle and collagen were examined. Results: Staining intensities of neuronal NOS and endothelial NOS were significantly lower in group D (p < .05). They were similar between group C and group D þ T. Immunoreactivity of inducible NOS was observed higher in group D than group C (p ¼ .01) whereas group D þ T had the highest iNOS (p< .001) and it was similar among group C and group D þ T (p ¼ .072). Group D had the lowest cGMP and NO levels (p < .05) and they did not differ between group C and group D þ T (p>.05). Group D and group D þ T had significantly decreased dihydrotestosterone and increased testosterone, compared to group C (p < .001). They were similar between group D and group D þ T. Conclusion: Daily treatment with tadalafil improves dutasteride-induced changes in rat penis |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1368-5538 1473-0790 |
| Relation: | https://doi.org/10.1080/13685538.2020.1739019; The Aging Male; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/20.500.12445/1894; 23; 161; 167 |
| DOI: | 10.1080/13685538.2020.1739019 |
| الاتاحة: | https://hdl.handle.net/20.500.12445/1894 https://doi.org/10.1080/13685538.2020.1739019 |
| Rights: | info:eu-repo/semantics/openAccess ; Attribution-NonCommercial-NoDerivs 3.0 United States ; http://creativecommons.org/licenses/by-nc-nd/3.0/us/ |
| رقم الانضمام: | edsbas.85196FBA |
| قاعدة البيانات: | BASE |
| تدمد: | 13685538 14730790 |
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| DOI: | 10.1080/13685538.2020.1739019 |