PAK3 downregulation induces cognitive impairment following cranial irradiation
| العنوان: | PAK3 downregulation induces cognitive impairment following cranial irradiation |
|---|---|
| المؤلفون: | Youn, BuHyun |
| بيانات النشر: | Zenodo |
| سنة النشر: | 2023 |
| المجموعة: | Zenodo |
| مصطلحات موضوعية: | Cranial radiation, Cognitive impairment, Dendritic spine, Intranasal administration, microRNA, p21-activated kinase 3 |
| الوصف: | Cranial irradiation is used for prophylactic brain radiotherapy as well as treatment of primary brain tumors. Despite its high efficiency, it often induces unexpected side effects, including cognitive dysfunction. Herein, we observed that mice exposed to cranial irradiation exhibited cognitive dysfunction, including altered spontaneous behavior, decreased spatial memory, and reduced novel object recognition. Analysis of actin cytoskeleton revealed that ionizing radiation (IR) disrupted the filamentous/globular actin (F/G-actin) ratio and downregulated the actin turnover signaling pathway p21-activated kinase 3 (PAK3)-LIM kinase 1 (LIMK1)-cofilin. Furthermore, we found that IR could upregulate microRNA-206-3p (miR-206-3p) targeting PAK3. As the inhibition of miR-206-3p through antagonist (antagomiR), IR-induced disruption of PAK3 signaling is restored. In addition, intranasal administration of antagomiR-206-3p recovered IR-induced cognitive impairment in mice. Our results suggest that cranial irradiation-induced cognitive impairment could be ameliorated by regulating PAK3 through antagomiR-206-3p, thereby affording a promising strategy for protecting cognitive function during cranial irradiation, and promoting quality of life in patients with radiation therapy. ; Funding provided by: National Research Foundation of Korea Crossref Funder Registry ID: https://ror.org/013aysd81 Award Number: 2020M2D9A2094156 Funding provided by: National Research Foundation of Korea Crossref Funder Registry ID: https://ror.org/013aysd81 Award Number: RS-2023-00207904 |
| نوع الوثيقة: | other/unknown material |
| اللغة: | unknown |
| Relation: | https://doi.org/10.7554/eLife.89221; https://zenodo.org/communities/dryad; https://doi.org/10.5061/dryad.w0vt4b8zt; oai:zenodo.org:10273292 |
| DOI: | 10.5061/dryad.w0vt4b8zt |
| الاتاحة: | https://doi.org/10.5061/dryad.w0vt4b8zt |
| Rights: | info:eu-repo/semantics/openAccess ; Creative Commons Zero v1.0 Universal ; https://creativecommons.org/publicdomain/zero/1.0/legalcode |
| رقم الانضمام: | edsbas.84C953AA |
| قاعدة البيانات: | BASE |
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