Academic Journal
Role of microRNA/epithelial�to�mesenchymal transition axis in the metastasis of bladder cancer
| العنوان: | Role of microRNA/epithelialâ��toâ��mesenchymal transition axis in the metastasis of bladder cancer |
|---|---|
| المؤلفون: | Ashrafizadeh, M., Hushmandi, K., Hashemi, M., Akbari, M.E., Kubatka, P., Raei, M., Koklesova, L., Shahinozzaman, M., Mohammadinejad, R., Najafi, M., Sethi, G., Kumar, A.P., Zarrabi, A. |
| سنة النشر: | 2020 |
| المجموعة: | Kerman University of Medical Sciences, Iran: Simorgh Research Repository Portal |
| الوصف: | Bladder cancer (BC) is the 11th most common diagnosed cancer, and a number of factors including environmental and genetic ones participate in BC development. Metastasis of BC cells into neighboring and distant tissues significantly reduces overall survival of patients with this lifethreatening disorder. Recently, studies have focused on revealing molecular pathways involved in metastasis of BC cells, and in this review, we focus on microRNAs (miRNAs) and their regulatory effect on epithelialâ��toâ��mesenchymal transition (EMT) mechanisms that can regulate metastasis. EMT is a vital process for migration of BC cells, and inhibition of this mechanism restricts invasion of BC cells. MiRNAs are endogenous nonâ��coding RNAs with 19â��24 nucleotides capable of regulating different cellular events, and EMT is one of them. In BC cells, miRNAs are able to both induce and/or inhibit EMT. For regulation of EMT, miRNAs affect different molecular pathways such as transforming growth factorâ��beta (TGFâ��β), Snail, Slug, ZEB1/2, CD44, NSBP1, which are, discussed in detail this review. Besides, miRNA/EMT axis can also be regulated by upstream mediators such as lncRNAs, circRNAs and targeted by diverse antiâ��tumor agents. These topics are also discussed here to reveal diverse molecular pathways involved in migration of BC cells and strategies to target them to develop effective therapeutics. © 2020 by the authors. Licensee MDPI, Basel, Switzerland. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | Ashrafizadeh, M. and Hushmandi, K. and Hashemi, M. and Akbari, M.E. and Kubatka, P. and Raei, M. and Koklesova, L. and Shahinozzaman, M. and Mohammadinejad, R. and Najafi, M. and Sethi, G. and Kumar, A.P. and Zarrabi, A. (2020) Role of microRNA/epithelial�to�mesenchymal transition axis in the metastasis of bladder cancer. Biomolecules, 10 (8). pp. 1-26. |
| الاتاحة: | http://eprints.kmu.ac.ir/37303/ https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089408402&doi=10.3390%2fbiom10081159&partnerID=40&md5=110503831f8d25c0ad2c56b9565a9e95 |
| رقم الانضمام: | edsbas.84126170 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |