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DataSheet_1_Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection.pdf

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العنوان: DataSheet_1_Plasticity of the Immune System in Children Following Treatment Interruption in HIV-1 Infection.pdf
المؤلفون: Katrine Schou Sandgaard (11201775), Ben Margetts (11201778), Teresa Attenborough (5928950), Triantafylia Gkouleli (11201781), Stuart Adams (474760), Mette Holm (6021020), Diana Gibb (324183), Deena Gibbons (9131999), Carlo Giaquinto (309067), Anita De Rossi (309068), Alasdair Bamford (11201784), Paolo Palma (490673), Benny Chain (133611), Athina S. Gkazi (11201787), Nigel Klein (18890)
سنة النشر: 2021
المجموعة: Smithsonian Institution: Digital Repository
مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, HIV-1, T cells, thymic output, antiretroviral treatment interruption, T cell receptor, immune repertoires, T cell receptor clonal expansions, high throughout sequencing
الوصف: It is intriguing that, unlike adults with HIV-1, children with HIV-1 reach a greater CD4 + T cell recovery following planned treatment cessation. The reasons for the better outcomes in children remain unknown but may be related to increased thymic output and diversity of T cell receptor repertoires. HIV-1 infected children from the PENTA 11 trial tolerated planned treatment interruption without adverse long-term clinical, virological, or immunological consequences, once antiretroviral therapy was re-introduced. This contrasts to treatment interruption trials of HIV-1 infected adults, who had rapid changes in T cells and slow recovery when antiretroviral therapy was restarted. How children can develop such effective immune responses to planned treatment interruption may be critical for future studies. PENTA 11 was a randomized, phase II trial of planned treatment interruptions in HIV-1-infected children (ISRCTN 36694210). In this sub-study, eight patients in long-term follow-up were chosen with CD4 + count>500/ml, viral load <50c/ml at baseline: four patients on treatment interruption and four on continuous treatment. Together with measurements of thymic output, we used high-throughput next generation sequencing and bioinformatics to systematically organize memory CD8 + and naïve CD4 + T cell receptors according to diversity, clonal expansions, sequence sharing, antigen specificity, and T cell receptor similarities following treatment interruption compared to continuous treatment. We observed an increase in thymic output following treatment interruption compared to continuous treatment. This was accompanied by an increase in T cell receptor clonal expansions, increased T cell receptor sharing, and higher sequence similarities between patients, suggesting a more focused T cell receptor repertoire. The low numbers of patients included is a limitation and the data should be interpreted with caution. Nonetheless, the high levels of thymic output and the high diversity of the T cell receptor repertoire in ...
نوع الوثيقة: dataset
اللغة: unknown
Relation: https://figshare.com/articles/dataset/DataSheet_1_Plasticity_of_the_Immune_System_in_Children_Following_Treatment_Interruption_in_HIV-1_Infection_pdf/15072507
DOI: 10.3389/fimmu.2021.643189.s001
الاتاحة: https://doi.org/10.3389/fimmu.2021.643189.s001
Rights: CC BY 4.0
رقم الانضمام: edsbas.7EAEEE32
قاعدة البيانات: BASE
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