Academic Journal
Microinjection of CART peptide 55��102 into the nucleus accumbens blocks amphetamine-induced locomotion
| العنوان: | Microinjection of CART peptide 55��102 into the nucleus accumbens blocks amphetamine-induced locomotion |
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| المساهمون: | J.-H. Kim, E. Creekmore, P. Vezina, Kim, Jeong Hoon |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Amphetamine/administration & dosage, Animals, Central Nervous System Stimulants/administration & dosage, Locomotion/drug effects, Locomotion/physiology, Male, Microinjections, Nerve Tissue Proteins, Nucleus Accumbens/drug effects, Nucleus Accumbens/physiology, Peptide Fragments/pharmacology, Peptide Fragments/physiology, Rats, Sprague-Dawley, Time Factors, CART, Amphetamine, Locomotion, Nucleus accumbens |
| الوصف: | The role played by the biologically active CART 55��102 peptide in NAcc AMPH induced locomotion was investigated. When microinjected alone into this site, none of the doses of CART 55��102 tested (0.1, 0.4, 1.0 or 2.5 關g/0.5 關l/side) produced effects on locomotion during a two-h test. However, when co-injected with AMPH (2.5 關g/0.5 關l/side) into the NAcc, moderately high (2.5 關g/side) and middle to high (0.4��2.5 關g/side) doses of CART 55��102 significantly attenuated the effects of AMPH on locomotion and rearing, respectively. These results indicate that CART peptides can exert an antagonistic effect on the generation of locomotion by AMPH in the NAcc. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 369~373 |
| اللغة: | unknown |
| تدمد: | 0143-4179 1532-2785 |
| Relation: | NEUROPEPTIDES; J02351; OAK-2003-01219; https://ir.ymlib.yonsei.ac.kr/handle/22282913/114379; http://www.sciencedirect.com/science/article/pii/S0143417903001070; T200306416; NEUROPEPTIDES, Vol.37(6) : 369-373, 2003 |
| DOI: | 10.1016/j.npep.2003.10.001 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/114379 https://doi.org/10.1016/j.npep.2003.10.001 http://www.sciencedirect.com/science/article/pii/S0143417903001070 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ ; not free |
| رقم الانضمام: | edsbas.7E4C03F5 |
| قاعدة البيانات: | BASE |
| تدمد: | 01434179 15322785 |
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| DOI: | 10.1016/j.npep.2003.10.001 |