Academic Journal
Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use
| العنوان: | Significance of MPV, RDW and PDW with the Severity and Mortality of COVID-19 and Effects of Acetylsalicylic Acid Use |
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| المؤلفون: | Aydınyılmaz, Faruk, Aksakal, Emrah, Pamukcu, Hilal Erken, Aydemir, Selim, Doğan, Remziye, Saraç, İbrahim, Aydın, Sidar Şiyar, Kalkan, Kamuran, Gülcü, Oktay, Tanboğa, İbrahim Halil |
| المصدر: | Clinical and Applied Thrombosis/Hemostasis ; volume 27 ; ISSN 1076-0296 1938-2723 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2021 |
| الوصف: | We aimed to investigate association between mean platelet volume (MVP), platelet distribution width (PDW) and red cell distribution width (RDW) and mortality in patients with COVID-19 and find out in which patients the use of acetylsalicylic acid (ASA) affects the prognosis due to the effect of MPV on thromboxan A2. A total of 5142 patients were divided into those followed in the intensive care unit (ICU) and those followed in the ward. Patient medical records were examined retrospectively. ROC analysis showed that the area under curve (AUC) values were 0.714, 0.750, 0.843 for MPV, RDW and D-Dimer, the cutoff value was 10.45fl, 43.65fl, 500.2 ng/mL respectively. (all P < .001). Survival analysis showed that patients with MPV >10.45 f/l and D-Dimer >500.2 ng/mL, treatment with ASA had lower in-hospital and 180-day mortality than patients without ASA in ICU patients (HR = 0.773; 95% CI = 0.595-0.992; P = .048, HR = 0.763; 95% CI = 0.590-0.987; P = .036). Administration of low-dose ASA in addition to anti-coagulant according to MPV and D-dimer levels reduces mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/10760296211048808 |
| الاتاحة: | https://doi.org/10.1177/10760296211048808 https://journals.sagepub.com/doi/pdf/10.1177/10760296211048808 https://journals.sagepub.com/doi/full-xml/10.1177/10760296211048808 |
| Rights: | https://creativecommons.org/licenses/by-nc/4.0/ |
| رقم الانضمام: | edsbas.7BA854C2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/10760296211048808 |
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