Academic Journal
The Role of Scavenger Receptor BI in Sepsis
| العنوان: | The Role of Scavenger Receptor BI in Sepsis |
|---|---|
| المؤلفون: | Dan Hao, Jian-Yao Xue, Qian Wang, Ling Guo, Xiang-An Li |
| المصدر: | International Journal of Molecular Sciences ; Volume 25 ; Issue 24 ; Pages: 13441 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2024 |
| المجموعة: | MDPI Open Access Publishing |
| مصطلحات موضوعية: | scavenger receptor BI, SR-BI, HDL, sepsis, adrenal stress response, glucocorticoid, precision medicine |
| جغرافية الموضوع: | agris |
| الوصف: | Sepsis is a life-threatening condition resulting from a dysregulated host response to infection. Currently, there is no effective therapy for sepsis due to an incomplete understanding of its pathogenesis. Scavenger receptor BI (SR-BI) is a high-density lipoprotein (HDL) receptor that plays a key role in HDL metabolism by modulating the selective uptake of cholesteryl ester from HDL. Recent studies, including those from our laboratory, indicate that SR-BI protects against sepsis through multiple mechanisms: (1) preventing nitric oxide-induced cytotoxicity; (2) promoting hepatic lipopolysaccharide (LPS) clearance and regulating cholesterol metabolism in the liver; (3) inhibiting LPS-induced inflammatory signaling in macrophages; and (4) mediating the uptake of cholesterol from HDL for inducible glucocorticoid (iGC) synthesis in the adrenal gland, which controls systemic inflammatory response. In this article, we review the roles of SR-BI in sepsis. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Molecular Pathology, Diagnostics, and Therapeutics; https://dx.doi.org/10.3390/ijms252413441 |
| DOI: | 10.3390/ijms252413441 |
| الاتاحة: | https://doi.org/10.3390/ijms252413441 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.78FF3813 |
| قاعدة البيانات: | BASE |
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