Academic Journal
Neck failure following pathologically node-negative neck dissection (pN0) in oral squamous cell carcinoma: a systematic review and meta-analysis
| العنوان: | Neck failure following pathologically node-negative neck dissection (pN0) in oral squamous cell carcinoma: a systematic review and meta-analysis |
|---|---|
| المؤلفون: | Chegini, S, Schilling, C, Walgama, ES, Yu, KM, Thankappan, K, Iyer, S, Cariati, P, Balasubramanian, D, Kanatas, A, Lai, SY, McGurk, M |
| بيانات النشر: | Elsevier |
| سنة النشر: | 2021 |
| المجموعة: | White Rose Research Online (Universities of Leeds, Sheffield & York) |
| الوصف: | Due to the risk of occult cervical metastasis, elective neck dissection (END) is recommended in the management of patients with early oral cavity squamous cell carcinoma (OSCC) and a clinically node-negative (cN0) neck. This paper presents a systematic review and meta-analysis of studies that recorded isolated regional recurrence (RR) in the pathologically node-negative neck dissection (pN0) neck following END in order to quantify the failure rate. Pubmed and Ovid databases were systematically searched for relevant articles published between January 2009 and January 2019. Studies reporting RR following END in patients with OSCC who had no pathological evidence of lymph node metastasis were eligible for inclusion in this meta-analysis. In addition, a selection of large head and neck units were invited to submit unpublished data. Search criteria produced a list of 5448 papers, of which 18 studies met the inclusion criteria. Three institutions contributed unpublished data. This included a total of 4824 patients with median follow-up of 34 months (2.8 years). Eight datasets included patients staged T1-T4 with RR 17.3% (469/2711), 13 datasets included patients staged T1-T2 with RR 7.5% (158/2113). Overall across all 21 studies, isolated neck recurrence was identified in 627 cases giving a RR of 13.0% (627/4824) on meta-analysis. Understanding the therapeutic effectiveness of END provides context for evaluation of clinical management of the cN0 in these patients. A pathologically negative neck does not guarantee against future recurrence. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| Relation: | https://eprints.whiterose.ac.uk/180911/3/node%20negative%20neck%20paper%20220720.pdf; Chegini, S, Schilling, C, Walgama, ES et al. (8 more authors) (2021) Neck failure following pathologically node-negative neck dissection (pN0) in oral squamous cell carcinoma: a systematic review and meta-analysis. British Journal of Oral and Maxillofacial Surgery, 59 (10). pp. 1157-1165. ISSN 0266-4356 |
| الاتاحة: | https://eprints.whiterose.ac.uk/180911/ https://eprints.whiterose.ac.uk/180911/3/node%20negative%20neck%20paper%20220720.pdf |
| Rights: | cc_by_nc_nd_4 |
| رقم الانضمام: | edsbas.75DFE375 |
| قاعدة البيانات: | BASE |
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