Academic Journal
SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies
| العنوان: | SARS-CoV-2 mRNA vaccination is not associated with the induction of anti-HLA or non-HLA antibodies |
|---|---|
| المؤلفون: | Wijtvliet, Veerle, Verheyden, Sonja, Depreter, Barbara, Heylen, Christine, Coeman, Elke, Abrams, Steven, De Winter, Benedicte, Massart, Annick, Hellemans, Rachel, Pipeleers, Lissa, Claas, Frans, Ariën, Kevin, Wissing, Karl Martin, Abramowicz, Daniel, Ledeganck, Kristien |
| المصدر: | 0966-3274 ; Transplant immunology |
| سنة النشر: | 2022 |
| المجموعة: | IRUA - Institutional Repository van de Universiteit Antwerpen |
| مصطلحات موضوعية: | Human medicine |
| الوصف: | Background: SARS-CoV-2 vaccination is strongly recommended in kidney transplant recipients (KTR) and dialysis patients. Whether these vaccinations may trigger alloantibodies, is still debated. Methods: In the current study we evaluated the effect of SARS-CoV-2 mRNA vaccines on anti-Human Leukocyte Antigen (HLA) and 60 anti-non-HLA antibody profiles in clinically stable KTR and dialysis patients. In total, we included 28 KTR, 30 patients on haemodialysis, 25 patients on peritoneal dialysis and 31 controls with a positive seroresponse 16-21 days after the first dose of either the SARS-CoV-2 mRNA BNT162b2 or mRNA-1273 vaccine. Both anti-HLA and anti-non-HLA antibodies were determined prior to vaccination and 21 to 35 days after the second vaccine dose. Results: Overall, the proportion of patients with detectable anti-HLA antibodies was similar before and after vaccination (class I 14% vs. 16%, p = 0.48; class II 25% before and after vaccination). After vaccination, there was no pattern in 1) additionally detected anti-HLA antibodies, or 2) the levels of pre-existing ones. Additional anti-non-HLA antibodies were detected in 30% of the patients, ranging from 1 to 5 new anti-non-HLA antibodies per patient. However, the clinical significance of anti-non-HLA antibodies is still a matter of debate. To date, only a significant association has been found for anti-non-HLA ARHGDIB antibodies and long-term kidney graft loss. No additionally developed anti-ARHGDIB antibodies or elevated level of existing anti-ARHGDIB antibodies was observed. Conclusion: The current data indicate that SARS-CoV-2 mRNA vaccination does not induce anti-HLA or anti-non-HLA antibodies, corroborating the importance of vaccinating KTR and dialysis patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/isi/000835335500014 |
| الاتاحة: | https://hdl.handle.net/10067/1893990151162165141 https://repository.uantwerpen.be/docstore/d:irua:13347 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.74538B42 |
| قاعدة البيانات: | BASE |
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