Academic Journal
Clinical association between pharmacogenomics and adverse drug reactions
| العنوان: | Clinical association between pharmacogenomics and adverse drug reactions |
|---|---|
| المؤلفون: | ZW Zhou, XW Chen, KB Sneed, YX Yang, X Zhang, ZX He, K Chow, T Yang, Wei Duan, SF Zhou |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Pharmacology and pharmaceutical sciences not elsewhere classified, School of Medicine, 111504 Pharmaceutical Sciences, 920102 Cancer and Related Disorders |
| الوصف: | Adverse drug reactions (ADRs) are a major public health concern and cause significant patient morbidity and mortality. Pharmacogenomics is the study of how genetic polymorphisms affect an individual's response to pharmacotherapy at the level of a whole genome. This article updates our knowledge on how genetic polymorphisms of important genes alter the risk of ADR occurrence after an extensive literature search. To date, at least 244 pharmacogenes identified have been associated with ADRs of 176 clinically used drugs based on PharmGKB. At least 28 genes associated with the risk of ADRs have been listed by the Food and Drug Administration as pharmacogenomic biomarkers. With the availability of affordable and reliable testing tools, pharmacogenomics looks promising to predict, reduce, and minimize ADRs in selected populations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | http://hdl.handle.net/10536/DRO/DU:30073291; https://figshare.com/articles/journal_contribution/Clinical_association_between_pharmacogenomics_and_adverse_drug_reactions/20908759 |
| الاتاحة: | http://hdl.handle.net/10536/DRO/DU:30073291 https://figshare.com/articles/journal_contribution/Clinical_association_between_pharmacogenomics_and_adverse_drug_reactions/20908759 |
| Rights: | All Rights Reserved |
| رقم الانضمام: | edsbas.6CAD1732 |
| قاعدة البيانات: | BASE |
كن أول من يترك تعليقا!