Academic Journal
IL-33 mediates multi-walled carbon nanotube (MWCNT)-induced airway hyper-reactivity via the mobilization of innate helper cells in the lung
| العنوان: | IL-33 mediates multi-walled carbon nanotube (MWCNT)-induced airway hyper-reactivity via the mobilization of innate helper cells in the lung |
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| المؤلفون: | Celine A. Beamer (14340136), Teri A. Girtsman (14340139), Benjamin P. Seaver (14340142), Krissy J. Finsaas (14340145), Christopher T. Migliaccio (10486459), Victoria K. Perry (14340148), James B. Rottman (14340151), Dirk E. Smith (14340154), Andrij Holian (78675) |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Medicine, Cell Biology, Physiology, Immunology, Developmental Biology, Cancer, Science Policy, Infectious Diseases, Space Science, Biological Sciences not elsewhere classified, Nanotoxicology, nanotubes, mechanistic toxicology |
| الوصف: | Allergic asthma is a chronic inflammatory disorder of the airway associated with bronchial obstruction, airway hyper-reactivity (AHR), and mucus production. The epithelium may direct and propagate asthmatic-like responses. Central to this theory is the observation that viruses, air pollution, and allergens promote epithelial damage and trigger the generation of IL-25, IL-33, and TSLP via innate pathways such as TLRs and purinergic receptors. Similarly, engineered nanomaterials promote a Th2-associated pathophysiology. In this study, we tested the hypothesis that instillation of multi-walled carbon nanotubes (MWCNT) impair pulmonary function in C57Bl/6 mice due to the development of IL-33-dependent Th2-associated inflammation. MWCNT exposure resulted in elevated levels of IL-33 in the lavage fluid (likely originating from airway epithelial cells), enhanced AHR, eosinophil recruitment, and production of Th2-associated cytokines and chemokines. Moreover, these events were dependent on IL-13 signaling and the IL-33/ST2 axis, but independent of T and B cells. Finally, MWCNT exposure resulted in the recruitment of innate lymphoid cells. Collectively, our data suggest that MWCNT induce epithelial damage that results in release of IL-33, which in turn promotes innate lymphoid cell recruitment and the development of IL-13-dependent inflammatory response. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/_b_IL-33_mediates_multi-walled_carbon_nanotube_MWCNT_-induced_airway_hyper-reactivity_via_the_mobilization_of_innate_helper_cells_in_the_lung_b_/21830332 |
| DOI: | 10.6084/m9.figshare.21830332.v1 |
| الاتاحة: | https://doi.org/10.6084/m9.figshare.21830332.v1 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.6BE55DBA |
| قاعدة البيانات: | BASE |
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