Academic Journal
P213 Risk factors associated with NAFLD and liver fibrosis in patients with Inflammatory Bowel Disease: a prospective cohort study
| العنوان: | P213 Risk factors associated with NAFLD and liver fibrosis in patients with Inflammatory Bowel Disease: a prospective cohort study |
|---|---|
| المؤلفون: | Martínez-Domínguez, S J, García Mateo, S, Gallego Llera, B, Gargallo-Puyuelo, C J, Refaie, E, Arroyo Villarino, M T, Laredo de la Torre, V, Alfambra Cabrejas, E, Gomollón García, F |
| المصدر: | Journal of Crohn's and Colitis ; volume 16, issue Supplement_1, page i269-i269 ; ISSN 1873-9946 1876-4479 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2022 |
| الوصف: | Background Non Alcoholic Fatty Liver Disease (NAFLD) prevalence is increasing quickly all over the world. A higher prevalence has been reported in Inflammatory Bowel Disease (IBD) patients. NAFLD is associated with increased mortality from liver and cardiovascular causes, so defining risk factors is clinically very relevant. Methods Consecutive IBD patients ≥ 18 years were evaluated at a reference center from October 2020 to April 2021, after giving their informed consent. They were investigated the presence of NAFLD by hepatic ultrasonography and Controlled Attenuation Parameter (CAP) performed by two trained gastroenterologists, considering steatosis in case of any degree of ultrasound steatosis or CAP > 245 dB/m. Risk of advanced liver fibrosis was considered if transient elastography was ≥ 8 kPa. Patients with risk alcohol consumption, secondary causes of steatosis or any chronic hepatic disease were excluded. In addition, a blood sample was obtained for biochemical parameters, clinical variables were recovered prospectively and medical records were reviewed. A descriptive analysis was carried out and factors potentially associated with NAFLD and liver fibrosis were analysed through logistic regression multivariate analyses. For all tests a two-sided p value <0.05 was considered statistically significant. The study was approved by local Ethical Committee. Results 700 patients (50% women) with a median age of 50 (IQR (40–60)) years were included. In 377 (53.9%) the diagnosis was Ulcerative Colitis and in 323 (46.1%) Crohn′s Disease, the median age at diagnosis was 33 (IQR (22–42)) years. 131 (18.7%) had obesity and 238 (34%) had overweight. The prevalence of NAFLD was 42.57% and the prevalence of liver fibrosis was 7.31%. In multivariate analysis, NAFLD was significantly associated with older age (OR (CI 95%) 1.04 (1.02–1.06), p <0.001), obesity/overweight (OR (CI 95%) 0.26 (0.17–0.39), p <0.001), waist-to-hit ratio (OR (CI 95%) 0.32 (0.21–0.48), p <0.001) and ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ecco-jcc/jjab232.340 |
| الاتاحة: | https://doi.org/10.1093/ecco-jcc/jjab232.340 https://academic.oup.com/ecco-jcc/article-pdf/16/Supplement_1/i269/42251160/jjab232.340.pdf |
| Rights: | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model |
| رقم الانضمام: | edsbas.6AC7ACB8 |
| قاعدة البيانات: | BASE |
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