Academic Journal
Clinicopathological characteristics, prognostic factors, and outcomes of elderly patients with lymphoma‐associated hemophagocytic lymphohistiocytosis: A multicenter analysis
| العنوان: | Clinicopathological characteristics, prognostic factors, and outcomes of elderly patients with lymphoma‐associated hemophagocytic lymphohistiocytosis: A multicenter analysis |
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| المؤلفون: | Miao, Yi, Zhang, Jing, Lu, Xuzhang, Wu, Meng, Li, Bingzong, Yu, Liang, Sun, Miao, Zhuang, Yun, Miao, Yuqing, Ni, Haiwen, Xie, Xiaoyan, Xu, Jingyan, Zhang, Yunping, Zhao, Min, Xu, Min, Zhuang, Wanchuan, Gu, Weiying, Lin, Guoqiang, Hua, Haiying, Zhu, Jianfeng, Xu, Maozhong, Jia, Tao, Liu, Ping, Zhai, Lijia, Zhang, Tongtong, Shan, Qiurong, Shen, Qiudan, Qian, Jun, Wang, Chunling, Li, Jianyong, Shi, Wenyu |
| المساهمون: | Natural Science Foundation of Jiangsu Province |
| المصدر: | Cancer Medicine ; volume 13, issue 16 ; ISSN 2045-7634 2045-7634 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background Lymphoma is the most common secondary cause of hemophagocytic lymphohistiocytosis (HLH) in adults. Lymphoma‐associated HLH (LA‐HLH) in the elderly population is not rare, however, little has been reported regarding clinicopathological characteristics, prognostic factors, and outcomes of LA‐HLH in the elderly population. Methods We retrospectively analyzed a multicenter cohort of elderly patients with LA‐HLH. Clinicopathological features and treatment information were collected. The impacts of baseline characteristics and treatments on survival outcomes were analyzed. Results A total of 173 elderly patients with LA‐HLH were included. Compared with young patients, elderly patients showed different clinical and laboratory features. Regarding lymphoma subtypes, B‐cell lymphoma was more common in elderly patients (elderly 61.3% vs. young 32.3%, p < 0.001) while T/NK‐cell lymphoma was more common in young patients (65.3% vs. 35.3%, p < 0.001). The median survival of elderly patients with LA‐HLH was only 92 days. The prior use of HLH therapy or etoposide‐containing HLH therapy was not associated with improved overall survival. T/NK‐cell subtype, a lower platelet count (≤53 × 10 9 /L), a lower albumin level (≤32.1 g/L), a higher LDH level (>1407 U/L), and a higher creatinine level (>96.8 μmol/L) were independent predictors of decreased overall survival and 60‐day survival. A prognostic index was established and demonstrated to be robust in predicting the overall survival and 60‐day survival of elderly patients with LA‐HLH. Conclusions LA‐HLH in elderly patients displayed heterogeneous clinicopathological features and survival outcomes. Treatments need to be optimized to improve the outcomes of elderly patients with LA‐HLH. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/cam4.70178 |
| الاتاحة: | http://dx.doi.org/10.1002/cam4.70178 https://onlinelibrary.wiley.com/doi/pdf/10.1002/cam4.70178 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.6A99AE4C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cam4.70178 |
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