Academic Journal
Robotic multi-probe single-actuator inchworm neural microdrive
| العنوان: | Robotic multi-probe single-actuator inchworm neural microdrive |
|---|---|
| المؤلفون: | Smith, Richard D, Kolb, Ilya, Tanaka, Shinsuke, Lee, Albert K, Harris, Timothy D, Barbic, Mladen |
| المساهمون: | Howard Hughes Medical Institute |
| المصدر: | eLife ; volume 11 ; ISSN 2050-084X |
| بيانات النشر: | eLife Sciences Publications, Ltd |
| سنة النشر: | 2022 |
| المجموعة: | eLife (E-Journal - via CrossRef) |
| الوصف: | A wide range of techniques in neuroscience involve placing individual probes at precise locations in the brain. However, large-scale measurement and manipulation of the brain using such methods have been severely limited by the inability to miniaturize systems for probe positioning. Here, we present a fundamentally new, remote-controlled micropositioning approach composed of novel phase-change material-filled resistive heater micro-grippers arranged in an inchworm motor configuration. The microscopic dimensions, stability, gentle gripping action, individual electronic control, and high packing density of the grippers allow micrometer-precision independent positioning of many arbitrarily shaped probes using a single piezo actuator. This multi-probe single-actuator design significantly reduces the size and weight and allows for potential automation of microdrives. We demonstrate accurate placement of multiple electrodes into the rat hippocampus in vivo in acute and chronic preparations. Our robotic microdrive technology should therefore enable the scaling up of many types of multi-probe applications in neuroscience and other fields. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7554/elife.71876 |
| الاتاحة: | http://dx.doi.org/10.7554/elife.71876 https://cdn.elifesciences.org/articles/71876/elife-71876-v2.pdf https://cdn.elifesciences.org/articles/71876/elife-71876-v2.xml https://elifesciences.org/articles/71876 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.6203D091 |
| قاعدة البيانات: | BASE |
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