Academic Journal
A Multicenter, Prospective, Observational, Cohort-Controlled Study of Clinical Outcomes Following Coronavirus Disease 2019 (COVID-19) Convalescent Plasma Therapy in Hospitalized Patients With COVID-19
| العنوان: | A Multicenter, Prospective, Observational, Cohort-Controlled Study of Clinical Outcomes Following Coronavirus Disease 2019 (COVID-19) Convalescent Plasma Therapy in Hospitalized Patients With COVID-19 |
|---|---|
| المؤلفون: | Chauhan, Lakshmi, Pattee, Jack, Ford, Joshay, Thomas, Chris, Lesteberg, Kelsey, Richards, Eric, Bernas, Carl A, Loi, Michele, Dumont, Larry, Annen, Kyle, Berg, Mary, Zirbes, Mercedes, Knight, Vijaya, Miller, Amanda, Jenkins, Timothy C, Bennett, Tellen D, Monkowski, Daniel, Boxer, Rebecca S, Beckham, J David |
| المساهمون: | Colorado Clinical and Translational Sciences Institute, Biomedical Advanced Research and Development Authority, NIH |
| المصدر: | Clinical Infectious Diseases ; volume 75, issue 1, page e466-e472 ; ISSN 1058-4838 1537-6591 |
| بيانات النشر: | Oxford University Press (OUP) |
| سنة النشر: | 2021 |
| الوصف: | Background The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused high inpatient mortality and morbidity throughout the world. COVID-19 convalescent plasma (CCP) has been utilized as a potential therapy for patients hospitalized with coronavirus disease 2019 (COVID-19) pneumonia. This study evaluated the outcomes of hospitalized patients with COVID-19 treated with CCP in a prospective, observational, multicenter trial. Methods From April through August 2020, hospitalized patients with COVID-19 at 16 participating hospitals in Colorado were enrolled and treated with CCP and compared with hospitalized patients with COVID-19 who were not treated with convalescent plasma. Plasma antibody levels were determined following the trial, given that antibody tests were not approved at the initiation of the trial. CCP-treated and untreated hospitalized patients with COVID-19 were matched using propensity scores followed by analysis for length of hospitalization and inpatient mortality. Results A total of 542 hospitalized patients with COVID-19 were enrolled at 16 hospitals across the region. A total of 468 hospitalized patients with COVID-19 were entered into propensity score matching with 188 patients matched for analysis in the CCP-treatment and control arms. Fine-Gray models revealed increased length of hospital stay in CCP-treated patients and no change in inpatient mortality compared with controls. In subgroup analysis of CCP-treated patients within 7 days of admission, there was no difference in length of hospitalization and inpatient mortality. Conclusions These data show that treatment of hospitalized patients with COVID-19 treated with CCP did not significantly improve patient hospitalization length of stay or inpatient mortality. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/cid/ciab834 |
| DOI: | 10.1093/cid/ciab834/40836095/ciab834.pdf |
| الاتاحة: | https://doi.org/10.1093/cid/ciab834 http://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciab834/40836095/ciab834.pdf https://academic.oup.com/cid/article-pdf/75/1/e466/46659391/ciab834.pdf |
| Rights: | https://academic.oup.com/pages/standard-publication-reuse-rights |
| رقم الانضمام: | edsbas.615F1D6F |
| قاعدة البيانات: | BASE |
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