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أعرض في EDS

New Insights into First-Line Therapy in Diffuse Large B-Cell Lymphoma: Are We Improving Outcomes?

التفاصيل البيبلوغرافية
العنوان: New Insights into First-Line Therapy in Diffuse Large B-Cell Lymphoma: Are We Improving Outcomes?
المؤلفون: Abrisqueta, Pau
المساهمون: Institut Català de la Salut, Abrisqueta P Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Experimental Hematology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus
المصدر: Scientia
بيانات النشر: MDPI
سنة النشر: 2024
مصطلحات موضوعية: Cèl·lules B - Tumors - Tractament, Limfomes - Tractament, Anticossos monoclonals - Ús terapèutic, Cèl·lules T - Ús terapèutic, DISEASES::Hemic and Lymphatic Diseases::Lymphatic Diseases::Lymphoproliferative Disorders::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell::Lymphoma, Large B-Cell, Diffuse, Other subheadings::Other subheadings::Other subheadings::/drug therapy, CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Antibodies, Monoclonal, ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Investigative Techniques::Immunologic Techniques::Immunization::Immunization, Passive::Adoptive Transfer::Immunotherapy, Adoptive, Bispecific, ENFERMEDADES::enfermedades hematológicas y linfáticas::enfermedades linfáticas::trastornos linfoproliferativos::linfoma::linfoma no Hodgkin::linfoma de células B::linfoma de células B grandes difuso, Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia, COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos monoclonales, TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::técnicas de investigación::técnicas inmunológicas::inmunización::inmunización pasiva::transferencia adoptiva::inmunoterapia adoptiva, péptidos y proteínas::proteínas::proteínas sanguíneas::inmunoproteínas::inmunoglobulinas::anticuerpos::anticuerpos biespecíficos
الوصف: Diffuse large B-cell lymphoma; First-line therapy; Novel therapies ; Limfoma difús de cèl·lules B grans; Teràpia de primera línia; Teràpies noves ; Linfoma difuso de células B grandes; Terapia de primera línea; Terapias novedosas ; Diffuse large B-cell lymphoma (DLBCL) is the most prevalent subtype of lymphoma, comprising heterogeneous patient subgroups with distinctive biological and clinical characteristics. The R-CHOP combination (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) has been the standard initial treatment, yielding prolonged remissions in over 60% of patients with advanced-stage disease. Several attempts to enhance the outcomes of this regimen over the last two decades have shown limited success. Various novel therapeutic approaches have recently emerged in lymphoma, demonstrating promising results. These include small molecules, novel monoclonal antibodies, antibody–drug conjugates (ADC), bispecific antibodies (BsAbs), and chimeric antigen receptor (CAR) T-cell therapy. This review explores recent advancements in therapeutic strategies for DLBCL and their potential impact on the initial management of DLBCL patients. ; This work was supported in part by the Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias [PI17/00943, PI22/01204].
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
ردمك: 978-0-01-200883-6
0-01-200883-4
تدمد: 2077-0383
Relation: Journal of Clinical Medicine;13(7); https://doi.org/10.3390/jcm13071929; info:eu-repo/grantAgreement/ES/PEICTI2021-2023/PI22%2F01204; info:eu-repo/grantAgreement/ES/PE2017-2020/PI17%2F00943; Abrisqueta P. New Insights into First-Line Therapy in Diffuse Large B-Cell Lymphoma: Are We Improving Outcomes? J Clin Med. 2024 Mar 27;13(7):1929.; https://hdl.handle.net/11351/11348; 001200883400001
DOI: 10.3390/jcm13071929
الاتاحة: https://hdl.handle.net/11351/11348
https://doi.org/10.3390/jcm13071929
Rights: Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ ; info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.5D9D4353
قاعدة البيانات: BASE
الوصف
ردمك:9780012008836
0012008834
تدمد:20770383
DOI:10.3390/jcm13071929