Academic Journal
Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial
| العنوان: | Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial |
|---|---|
| المؤلفون: | Stewart, GM, Johnson, BD, Sprecher, DL, Reddy, YNV, Obokata, M, Goldsmith, S, Bart, B, Oughton, A, Fillmore, C, Behm, DJ, Borlaug, BA |
| بيانات النشر: | Wiley |
| سنة النشر: | 2020 |
| المجموعة: | Griffith University: Griffith Research Online |
| مصطلحات موضوعية: | Cardiovascular medicine and haematology, Clinical pharmacology and therapeutics, Extravascular lung water, Lung diffusion, Pharmacotherapy, Transient receptor potential vanilloid 4 |
| الوصف: | Aims: Lung congestion in patients with heart failure (HF) has traditionally been treated using interventions that reduce pulmonary capillary hydrostatic pressure. The transient receptor potential vanilloid 4 (TRPV4) channel regulates fluid transit across the pulmonary capillary-interface, and represents a novel target to reduce lung water, independent of pulmonary capillary hypertension. This pilot study examined the safety and potential efficacy of TRPV4 blockade as a novel treatment for HF. Methods and results: In this randomized, double-blind, placebo-controlled crossover pilot trial, 11 subjects with chronic, compensated HF were treated with a novel TRPV4 antagonist (GSK2798745) or placebo. The primary endpoint was lung diffusing capacity for carbon monoxide (DLCO) after 7 days of treatment with GSK2798745 as compared to placebo. Secondary endpoints included additional diffusion parameters, spirometry and safety assessments. Compared to placebo, treatment with GSK2798745 resulted in a trend to improvement in DLCO (placebo: −0.336 mL/mmHg/min; GSK2798745: +0.458 mL/mmHg/min; treatment difference: +0.793 mL/mmHg/min; 95% confidence interval: −0.925 to 2.512) that was not statistically significant. GSK2798745 was well-tolerated with no serious adverse events. Conclusion: In this pilot trial, GSK2798745 was found to be safe and well-tolerated, with a trend toward improved gas transfer. Further investigation is warranted in larger studies to determine whether treatment with TRPV4 antagonists or alternative treatments targeting capillary permeability might be effective to improve lung congestion, pulmonary gas transfer and clinical status in patients with acute or chronic HF. ; No Full Text |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1388-9842 |
| Relation: | European Journal of Heart Failure; Stewart, GM; Johnson, BD; Sprecher, DL; Reddy, YNV; Obokata, M; Goldsmith, S; Bart, B; Oughton, A; Fillmore, C; Behm, DJ; Borlaug, BA, Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial, European Journal of Heart Failure, 2020, 22 (9), pp. 1641-1645; http://hdl.handle.net/10072/412286 |
| DOI: | 10.1002/ejhf.1809 |
| الاتاحة: | http://hdl.handle.net/10072/412286 https://doi.org/10.1002/ejhf.1809 |
| Rights: | open access |
| رقم الانضمام: | edsbas.5AE0B352 |
| قاعدة البيانات: | BASE |
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