Academic Journal
Transgenic expression of Ly49A on T cells impairs a specific antitumor response.
| العنوان: | Transgenic expression of Ly49A on T cells impairs a specific antitumor response. |
|---|---|
| المؤلفون: | Brawand, P., Lemonnier, F.A., MacDonald, H.R., Cerottini, J.C., Held, W. |
| المصدر: | Journal of immunology, vol. 165, no. 4, pp. 1871-1876 |
| سنة النشر: | 2000 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Animals, Antigens, Ly, Viral/immunology, CD4-Positive T-Lymphocytes/immunology, CD8-Positive T-Lymphocytes/immunology, Carrier Proteins/biosynthesis, Carrier Proteins/genetics, Dose-Response Relationship, Immunologic, Epitopes, T-Lymphocyte/immunology, Gene Expression Regulation/immunology, Graft Rejection/genetics, Graft Rejection/immunology, H-2 Antigens/metabolism, Immunodominant Epitopes/immunology, Lectins, C-Type, Leukemia, Experimental/immunology, Experimental/prevention &, control, Lymphocyte Activation/genetics, Lymphopenia/genetics, Lymphopenia/immunology, Membrane Proteins/biosynthesis, Membrane Proteins/genetics, Mice, Inbred C57BL |
| الوصف: | Inhibitory MHC receptors determine the reactivity and specificity of NK cells. These receptors can also regulate T cells by modulating TCR-induced effector functions such as cytotoxicity, cytokine production, and proliferation. Here we have assessed the capacity of mouse T cells expressing the inhibitory MHC class I receptor Ly49A to respond to a well-defined tumor Ag in vivo using Ly49A transgenic mice. We find that the presence of Ly49A on the vast majority of lymphocytes prevents the development of a significant Ag-specific CD8+ T cell response and, consequently, the rejection of the tumor. Despite minor alterations in the TCR repertoire of CD8+ T cells in the transgenic lines, precursors of functional tumor-specific CD8+ T cells exist but could not be activated most likely due to a lack of appropriate CD4+ T cell help. Surprisingly, all of these effects are observed in the absence of a known ligand for the Ly49A receptor as defined by its ability to regulate NK cell function. Indeed, we found that the above effects on T cells may be based on a weak interaction of Ly49A with Kb or Db class I molecules. Thus, our data demonstrate that enforced expression of a Ly49A receptor on conventional T cells prevents a specific immune response in vivo and suggest that the functions of T and NK cells are differentially sensitive to the presence of inhibitory MHC class I receptors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/10925266; info:eu-repo/semantics/altIdentifier/pissn/0022-1767; https://serval.unil.ch/notice/serval:BIB_8D644545DCE9 |
| الاتاحة: | https://serval.unil.ch/notice/serval:BIB_8D644545DCE9 |
| رقم الانضمام: | edsbas.5A52F380 |
| قاعدة البيانات: | BASE |
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