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Image_1_Elevated Humoral Immune Response to SARS-CoV-2 at High Altitudes Revealed by an Anti-RBD “In-House” ELISA.TIF
| العنوان: | Image_1_Elevated Humoral Immune Response to SARS-CoV-2 at High Altitudes Revealed by an Anti-RBD “In-House” ELISA.TIF |
|---|---|
| المؤلفون: | Rodrigo Hernán Tomas-Grau (11562103), Diego Ploper (10342487), César Luis Ávila (11562106), Esteban Vera Pingitore (11562109), Carolina Maldonado Galdeano (11562112), Silvina Chaves (11562115), Sergio Benjamín Socias (11562118), Agustín Stagnetto (11562121), Silvia Adriana Navarro (11562124), Rossana Elena Chahla (11562127), Mónica Aguilar López (11562130), Conrado Juan Llapur (11562133), Patricia Aznar (3876421), María Elena Alcorta (11562136), Dardo Costas (11562139), Isolina Flores (11562142), Dar Heinze (11562145), Gabriela Apfelbaum (11562148), Raul Mostoslavsky (369241), Gustavo Mostoslavsky (110612), Silvia Inés Cazorla (9503666), Gabriela del Valle Perdigón (11562151), Rosana Chehín (10342502) |
| سنة النشر: | 2021 |
| المجموعة: | Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: | Dermatology, Emergency Medicine, Gastroenterology and Hepatology, Geriatrics and Gerontology, Intensive Care, Medical Genetics (excl. Cancer Genetics), Nephrology and Urology, Nuclear Medicine, Orthopaedics, Otorhinolaryngology, Pathology (excl. Oral Pathology), Radiology and Organ Imaging, Foetal Development and Medicine, Obstetrics and Gynaecology, Family Care, Primary Health Care, Medical and Health Sciences not elsewhere classified, COVID-19, high altitude, SARS-CoV-2, RBD, ELISA |
| الوصف: | The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a global pandemic with dramatic health and socioeconomic consequences. The Coronavirus Disease 2019 (COVID-19) challenges health systems to quickly respond by developing new diagnostic strategies that contribute to identify infected individuals, monitor infections, perform contact-tracing, and limit the spread of the virus. In this brief report, we developed a highly sensitive, specific, and precise “In-House” ELISA to correctly discriminate previously SARS-CoV-2-infected and non-infected individuals and study population seroprevalence. Among 758 individuals evaluated for anti-SARS-CoV-2 serology in the province of Tucumán, Argentina, we found a weak correlation between antibodies elicited against the RBD, the receptor-binding domain of the Spike protein, and the nucleocapsid (N) antigens of this virus. Additionally, we detected mild levels of anti-RBD IgG antibodies in 33.6% of individuals diagnosed with COVID-19, while only 19% showed sufficient antibody titers to be considered as plasma donors. No differences in IgG anti-RBD titers were found between women and men, neither in between different age groups ranging from 18 to 60. Surprisingly, individuals from a high altitude village displayed elevated and longer lasting anti-RBD titers compared to those from a lower altitude city. To our knowledge, this is the first report correlating altitude with increased humoral immune response against SARS-CoV-2 infection. |
| نوع الوثيقة: | still image |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/figure/Image_1_Elevated_Humoral_Immune_Response_to_SARS-CoV-2_at_High_Altitudes_Revealed_by_an_Anti-RBD_In-House_ELISA_TIF/16809268 |
| DOI: | 10.3389/fmed.2021.720988.s001 |
| الاتاحة: | https://doi.org/10.3389/fmed.2021.720988.s001 |
| Rights: | CC BY 4.0 |
| رقم الانضمام: | edsbas.59E8141 |
| قاعدة البيانات: | BASE |
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