Academic Journal
Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy
| العنوان: | Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy |
|---|---|
| المؤلفون: | Fan, Ying, Zhang, Jing, Xiao, Wenzhen, Lee, Kyung, Li, Zhengzhe, Wen, Jiejun, He, Li, Gui, Dingkun, Xue, Rui, Jian, Guihua, Sheng, Xiaohua, He, John Cijiang, Wang, Niansong |
| المصدر: | Scientific Reports ; volume 7, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2017 |
| الوصف: | We previously reported a critical role of reticulon (RTN) 1A in mediating endoplasmic reticulum (ER) stress in kidney tubular cells and the expression of RTN1A correlates with the renal function and the severity of kidney injury in patients with diabetic nephropathy (DN). Here, we determined the roles of RTN1A and ER stress in podocyte injury and DN. We used db/db mice with early unilateral nephrectomy (Unx) as a murine model of progressive DN and treated mice with tauroursodeoxycholic acid (TUDCA), a specific inhibitor of ER stress. We found increased expression of RTN1A and ER stress markers in the kidney of db/db-Unx mice. Treatment of TUDCA not only attenuated proteinuria and kidney histological changes, but also ameliorated podocyte and glomeruli injury in diabetic mice, which were associated with reduction of RTN1A and ER stress marker expression in the podocytes of TUDCA-treated mice. In vitro , we showed RTN1A mediates albumin-induced ER stress and apoptosis in human podocytes. A positive feedback loop between RTN1A and CHOP was found leading to an enhanced ER stress in podocytes. Our data suggest that ER stress plays a major role in podocyte injury in DN and RTN1A might be a key regulator of ER stress in podocytes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-017-00305-6 |
| الاتاحة: | http://dx.doi.org/10.1038/s41598-017-00305-6 https://www.nature.com/articles/s41598-017-00305-6.pdf https://www.nature.com/articles/s41598-017-00305-6 |
| Rights: | https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 |
| رقم الانضمام: | edsbas.58402FFB |
| قاعدة البيانات: | BASE |
| ResultId |
1 |
|---|---|
| Header |
edsbas BASE edsbas.58402FFB 871 3 Academic Journal academicJournal 871.106628417969 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.58402FFB&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => http://dx.doi.org/10.1038/s41598-017-00305-6# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Fan%2C+Ying%22">Fan, Ying</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Jing%22">Zhang, Jing</searchLink><br /><searchLink fieldCode="AR" term="%22Xiao%2C+Wenzhen%22">Xiao, Wenzhen</searchLink><br /><searchLink fieldCode="AR" term="%22Lee%2C+Kyung%22">Lee, Kyung</searchLink><br /><searchLink fieldCode="AR" term="%22Li%2C+Zhengzhe%22">Li, Zhengzhe</searchLink><br /><searchLink fieldCode="AR" term="%22Wen%2C+Jiejun%22">Wen, Jiejun</searchLink><br /><searchLink fieldCode="AR" term="%22He%2C+Li%22">He, Li</searchLink><br /><searchLink fieldCode="AR" term="%22Gui%2C+Dingkun%22">Gui, Dingkun</searchLink><br /><searchLink fieldCode="AR" term="%22Xue%2C+Rui%22">Xue, Rui</searchLink><br /><searchLink fieldCode="AR" term="%22Jian%2C+Guihua%22">Jian, Guihua</searchLink><br /><searchLink fieldCode="AR" term="%22Sheng%2C+Xiaohua%22">Sheng, Xiaohua</searchLink><br /><searchLink fieldCode="AR" term="%22He%2C+John+Cijiang%22">He, John Cijiang</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+Niansong%22">Wang, Niansong</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Scientific Reports ; volume 7, issue 1 ; ISSN 2045-2322 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => Springer Science and Business Media LLC ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2017 ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => We previously reported a critical role of reticulon (RTN) 1A in mediating endoplasmic reticulum (ER) stress in kidney tubular cells and the expression of RTN1A correlates with the renal function and the severity of kidney injury in patients with diabetic nephropathy (DN). Here, we determined the roles of RTN1A and ER stress in podocyte injury and DN. We used db/db mice with early unilateral nephrectomy (Unx) as a murine model of progressive DN and treated mice with tauroursodeoxycholic acid (TUDCA), a specific inhibitor of ER stress. We found increased expression of RTN1A and ER stress markers in the kidney of db/db-Unx mice. Treatment of TUDCA not only attenuated proteinuria and kidney histological changes, but also ameliorated podocyte and glomeruli injury in diabetic mice, which were associated with reduction of RTN1A and ER stress marker expression in the podocytes of TUDCA-treated mice. In vitro , we showed RTN1A mediates albumin-induced ER stress and apoptosis in human podocytes. A positive feedback loop between RTN1A and CHOP was found leading to an enhanced ER stress in podocytes. Our data suggest that ER stress plays a major role in podocyte injury in DN and RTN1A might be a key regulator of ER stress in podocytes. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1038/s41598-017-00305-6 ) Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => http://dx.doi.org/10.1038/s41598-017-00305-6<br />https://www.nature.com/articles/s41598-017-00305-6.pdf<br />https://www.nature.com/articles/s41598-017-00305-6 ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => https://creativecommons.org/licenses/by/4.0 ; https://creativecommons.org/licenses/by/4.0 ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.58402FFB ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1038/s41598-017-00305-6
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Rtn1a-Mediated Endoplasmic Reticulum Stress in Podocyte Injury and Diabetic Nephropathy
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Fan, Ying
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Zhang, Jing
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Xiao, Wenzhen
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Lee, Kyung
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Li, Zhengzhe
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Wen, Jiejun
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => He, Li
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Gui, Dingkun
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Xue, Rui
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jian, Guihua
)
)
)
[10] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Sheng, Xiaohua
)
)
)
[11] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => He, John Cijiang
)
)
)
[12] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Wang, Niansong
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Type] => published
[Y] => 2017
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-locals
[Value] => edsbas
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsbas.oa
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Scientific Reports ; volume 7, issue 1 ; ISSN 2045-2322
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |