Academic Journal
Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients
| العنوان: | Structural Connectivity-Based Parcellation of the Dopaminergic Midbrain in Healthy Subjects and Schizophrenic Patients |
|---|---|
| المؤلفون: | Gianpaolo Antonio Basile, Alessia Bramanti, Salvatore Bertino, Giuseppina Cutroneo, Antonio Bruno, Adriana Tisano, Giuseppe Paladina, Demetrio Milardi, Giuseppe Anastasi |
| المصدر: | Medicina; Volume 56; Issue 12; Pages: 686 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2020 |
| المجموعة: | MDPI Open Access Publishing |
| مصطلحات موضوعية: | schizophrenia, midbrain, substantia nigra, diffusion weighted imaging tractography, ventral tegmental area, neuroimaging |
| الوصف: | Background and objectives: Functional deregulation of dopaminergic midbrain regions is a core feature of schizophrenia pathophysiology. Anatomical research on primates suggests that these regions may be subdivided into distinct, topographically organized functional territories according to their connectivity to the striatum. The aim of the present work was the reconstruction of dopaminergic midbrain subregions in healthy subjects and schizophrenic patients and the evaluation of their structural connectivity profiles. Materials and Methods: A hypothesis-driven connectivity-based parcellation derived from diffusion tractography was applied on 24 healthy subjects and 30 schizophrenic patients to identify distinct territories within the human dopaminergic midbrain in vivo and non-invasively. Results: We identified a tripartite subdivision of dopaminergic midbrain, including limbic, prefrontal and sensorimotor territories. No significant differences in structural features or connectivity were found between subjects and patients. Conclusions: The parcellation scheme proposed herein may help to achieve detailed characterization of structural and functional anomalies of the dopaminergic midbrain in schizophrenic patients. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Neurology; https://dx.doi.org/10.3390/medicina56120686 |
| DOI: | 10.3390/medicina56120686 |
| الاتاحة: | https://doi.org/10.3390/medicina56120686 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.57963A06 |
| قاعدة البيانات: | BASE |
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