Academic Journal
Factors associated with non-attendance at scheduled infant follow-up visits in an observational cohort of HIV-exposed infants in South Africa, 2012–2014
| العنوان: | Factors associated with non-attendance at scheduled infant follow-up visits in an observational cohort of HIV-exposed infants in South Africa, 2012–2014 |
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| المؤلفون: | Ngandu, Nobubelo Kwanele, Jackson, Debra, Lombard, Carl, Nsibande, Duduzile Faith, Dinh, Thu-Ha, Magasana, Vuyolwethu, Mogashoa, Mary, Goga, Ameena Ebrahim |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2019 |
| المجموعة: | University of Pretoria: UPSpace |
| مصطلحات موضوعية: | HIV-exposed infants, Postnatal care, Missed visits, Human immunodeficiency virus (HIV), South Africa (SA), HIV exposed uninfected (HEU), Infants, Antiretroviral therapy (ART) |
| الوصف: | BACKGROUND : Since 2001 the South African guidelines to improve child health and prevent vertical HIV transmission recommended frequent infant follow-up with HIV testing at 18 months postpartum. We sought to understand non-attendance at scheduled follow-up study visits up to 18 months, and for the 18-month infant HIV test amongst a nationally representative sample of HIV exposed uninfected (HEU) infants from a high HIV-prevalence African setting. METHODS : Secondary analysis of data drawn from a nationally representative observational cohort study (conducted during October 2012 to September 2014) of HEU infants and their primary caregivers was undertaken. Participants were eligible (N = 2650) if they were 4–8 weeks old and HEU at enrolment. All enrolled infants were followed up every 3months up to 18months. Each follow-up visit was scheduled to coincide with each child’s routine health visit, where possible. The denominator at each time point comprised HEU infants who were alive and HIV-free at the previous visit. We assessed baseline maternal and early HIV care characteristics associated with the frequency of ‘Missed visits’ (MV-frequency), using a negative binomial regression model adjusting for the follow-up time in the study, and associated with missed visits at 18 months (18-month MV) using a logistic regression model. RESULTS : The proportion of eligible infants with MV was lowest at 3 months (32.7%) and 18 months (31.0%) and highest at 12 months (37.6%). HIV-positive mothers not on triple antiretroviral therapy (ART) by 6-weeks postpartum had a significantly increased occurrence rate of ‘MV-frequency’ (adjusted incidence rate ratio, 1.2 (95% confidence interval (CI), 1.1–1.4), p < 0.0001). Compared to those mothers with ART, these mothers also increased the risk of ‘18-month-MV’ (adjusted odds ratio, 1.3 (CI, 1.1–1.6), p = 0.006). Unknown infant nevirapine-intake status increased the rate of ‘MV-frequency’ (p = 0.02). Mothers > 24 years had a significantly reduced rate of ‘MV-frequency’ (p ≤ 0.01) ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | http://hdl.handle.net/2263/75130; 1471-2334 (online) |
| DOI: | 10.1186/s12879-019-4340-5 |
| الاتاحة: | http://hdl.handle.net/2263/75130 https://doi.org/10.1186/s12879-019-4340-5 |
| Rights: | © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License. |
| رقم الانضمام: | edsbas.50835690 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12879-019-4340-5 |
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