Conference
The Role of Axin in Dendrite and Spine Development
| العنوان: | The Role of Axin in Dendrite and Spine Development |
|---|---|
| المؤلفون: | Liang, Zhuoyi LIFS, Chen, Yu, Fei, Erkang, Fang, Weiqun, Fu, Ada Wing Yu, Fu, Amy Kit Yu, Ip, Nancy Yuk-Yu |
| سنة النشر: | 2014 |
| المجموعة: | The Hong Kong University of Science and Technology: HKUST Institutional Repository |
| الوصف: | Precise coordination of extracellular and intrinsic factors is critical for various developmental processes during the formation of the mammalian cerebral cortex. Among the scaffold proteins which serve as platforms for the formation of multi-signaling components to transduce extracellular signals to intracellular targets, Axin (axis inhibitor) is one that is expressed at high levels in mouse brain at embryonic and postnatal stages. Our laboratory recently reported that Axin and its phosphorylation at Thr485 by cyclin-dependent kinase 5 (Cdk5) is crucial for the cerebral cortex development, particularly in the regulation of embryonic neurogenesis and axon outgrowth. However, the roles of Axin in other neurodevelopmental processes remain unclear. Interestingly, we found that Axin and its Thr485 phosphorylated form were enriched in the post-synaptic compartments in mouse brain, and well co-localized with post-synaptic marker PSD-95. Whereas knockdown of Axin by targeted shRNA impaired dendritic growth and reduced the density of dendritic spines in cultured hippocampal neurons, these developmental defects could be rescued by re-expression of the RNAi-resistant Axin construct. In addition, stabilization of Axin increased the phosphorylation of GluA receptors at Ser831. Taken together, our study suggests that Axin plays a critical role in dendrite and spine development in the hippocampus. |
| نوع الوثيقة: | conference object |
| اللغة: | English |
| Relation: | http://repository.ust.hk/ir/Record/1783.1-70644; The 44th Annual Meeting of the Society for Neuroscience, Washington, USA, 15-19 November 2014; http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=&rft.volume=&rft.issue=&rft.date=2014&rft.spage=&rft.aulast=Liang&rft.aufirst=&rft.atitle=The%20Role%20of%20Axin%20in%20Dendrite%20and%20Spine%20Development&rft.title=The%2044th%20Annual%20Meeting%20of%20the%20Society%20for%20Neuroscience,%20Washington,%20USA,%2015-19%20November%202014 |
| الاتاحة: | http://repository.ust.hk/ir/Record/1783.1-70644 http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=&rft.volume=&rft.issue=&rft.date=2014&rft.spage=&rft.aulast=Liang&rft.aufirst=&rft.atitle=The%20Role%20of%20Axin%20in%20Dendrite%20and%20Spine%20Development&rft.title=The%2044th%20Annual%20Meeting%20of%20the%20Society%20for%20Neuroscience,%20Washington,%20USA,%2015-19%20November%202014 |
| رقم الانضمام: | edsbas.4D2AA8F0 |
| قاعدة البيانات: | BASE |
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