Academic Journal
An isoform of Dicer protects mammalian stem cells against multiple RNA viruses
| العنوان: | An isoform of Dicer protects mammalian stem cells against multiple RNA viruses |
|---|---|
| المؤلفون: | Poirier, Enzo Z., Buck, Michael D., Chakravarty, Probir, Carvalho, Joana, Frederico, Bruno, Cardoso, Ana, Healy, Lyn, Ulferts, Rachel, Beale, Rupert, Reis e Sousa, Caetano |
| المساهمون: | European Molecular Biology Organization, Wellcome, H2020 European Research Council, H2020 Marie Skłodowska-Curie Actions, Cancer Research UK, UK Medical Research Council, Louis-Jeantet Foundation |
| المصدر: | Science ; volume 373, issue 6551, page 231-236 ; ISSN 0036-8075 1095-9203 |
| بيانات النشر: | American Association for the Advancement of Science (AAAS) |
| سنة النشر: | 2021 |
| الوصف: | An antiviral Dicer defends stem cells Stem cells have a pivotal role in maintaining tissue architecture, integrity, and renewal. Poirier et al. demonstrate that mammalian stem cells can protect themselves from some RNA viruses by expressing an alternatively spliced isoform of the enzyme Dicer called aviD, which potentiates antiviral RNA interference (see the Perspective by Shahrudin and Ding). aviD acts by cleaving long, base-paired viral RNAs to generate small interfering RNAs that direct the sequence-specific cleavage of homologous viral RNAs. This process is reminiscent of that in insects and worms, which also use Dicer-dependent RNA interference in antiviral defense, and contrasts with mammalian differentiated cells, which generally rely on the interferon system to combat virus infection. Science , abg2264, this issue p. 231 ; see also abj5673, p. 160 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1126/science.abg2264 |
| الاتاحة: | http://dx.doi.org/10.1126/science.abg2264 https://syndication.highwire.org/content/doi/10.1126/science.abg2264 https://www.science.org/doi/pdf/10.1126/science.abg2264 |
| رقم الانضمام: | edsbas.4CD3617C |
| قاعدة البيانات: | BASE |
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