التفاصيل البيبلوغرافية
| العنوان: |
Reappraisal of [18F]FDG-PET/CT for diagnosis and management of cardiac implantable electronic device infections |
| المؤلفون: |
Miró Meda, José M., HernándezMeneses,Marta, Perissinotti, Andrés, Páez Martínez, Silvia, Llopis Pérez, Jaime, Dahl, Anders, Sandoval, Elena, Falces Salvador, Carles, Ambrosioni, Juan, Vidal, Bàrbara, Marco, Francesc, Cuervo Requena, Guillermo, Moreno Poyato, Antonio Rafael, Bosch Mestres, Jordi, Tolosana, José M. (José María), Fuster Pelfort, David, Hospital Clínic of Barcelona Infective Endocarditis Team Investigators |
| المصدر: |
Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
| بيانات النشر: |
Elsevier España |
| سنة النشر: |
2023 |
| المجموعة: |
Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: |
Endocarditis, Marcapassos, Infeccions, Desfibril·ladors cardioversors implantables, Cardiac pacemakers, Infections, Implantable cardioverter-defibrillators |
| الوصف: |
Introduction and objectives: The role of [18F]FDG-PET/CT in cardiac implantable electronic device (CIED) infections requires better evaluation, especially in the diagnosis of systemic infections. We aimed to determine the following: a) the diagnostic accuracy of [18F]FDG-PET/CT in each CIED topographical region, b) the added value of [18F]FDG-PET/CT over transesophageal echocardiography (TEE) in diagnosing systemic infections, c) spleen and bone marrow uptake in differentiating isolated local infections from systemic infections, and d) the potential application of [18F]FDG-PET/CT in follow-up. Methods: Retrospective single-center study including 54 cases and 54 controls from 2014 to 2021. The Primary endpoint was the diagnostic yield of [18F]FDG-PET/CT in each topographical CIED region. Secondary analyses described the performance of [18F]FDG-PET/CT compared with that of TEE in systemic infections, bone marrow and spleen uptake in systemic and isolated local infections, and the potential application of [18F]FDG-PET/CT in guiding cessation of chronic antibiotic suppression when completed device removal is not performed. Results: We analyzed 13 (24%) isolated local infections and 41 (76%) systemic infections. Overall, the specificity of [18F]FDG-PET/CT was 100% and sensitivity 85% (79% pocket, 57% subcutaneous lead, 22% endovascular lead, 10% intracardiac lead). When combined with TEE, [18F]FDG-PET/CT increased definite diagnosis o fsystemic infections from 34% to 56% (P=.04). Systemic infections with bacteremia showed higher spleen (P=.05) and bone marrow metabolism (P=.04) than local infections. Thirteen patients without complete device removal underwent a follow-up [18F]FDG-PET/CT, with no relapses after discontinuation of chronic antibiotic suppression in 6 cases with negative follow-up [18F]FDG-PET/CT. Conclusions: The sensitivity of [18F]FDG-PET/CT for evaluating CIED infections was high in local infections but much lower in systemic infections. However, accuracy increased when [18F]FDG-PET/CT was combined ... |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
10 p.; application/pdf |
| اللغة: |
English |
| تدمد: |
0300-8932 |
| Relation: |
Versió postprint del document publicat a: https://doi.org/10.1016/j.rec.2023.04.001; Revista Española de Cardiologia, 2023, vol. 76, num.12, p. 970-979; https://doi.org/10.1016/j.rec.2023.04.001; http://hdl.handle.net/2445/209329; 739254; 9349813 |
| الاتاحة: |
http://hdl.handle.net/2445/209329 |
| Rights: |
cc-by-nc-nd (c) Elsevier España, 2023 ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.4C638D9C |
| قاعدة البيانات: |
BASE |
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