التفاصيل البيبلوغرافية
| العنوان: |
Redox-Responsive Heparin–Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity |
| المؤلفون: |
Abegaz Tizazu Andrgie, Yihenew Simegniew Birhan, Tefera Worku Mekonnen, Endiries Yibru Hanurry, Haile Fentahun Darge, Rong-Ho Lee, Hsiao-Ying Chou, Hsieh-Chih Tsai |
| المصدر: |
Polymers; Volume 12; Issue 1; Pages: 43 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
chlorambucil, combination chemotherapy, heparin, prodrug, self-assembly |
| الوصف: |
Polymeric prodrug-based delivery systems have been extensively studied to find a better solution for the limitations of a single drug and to improve the therapeutic and pharmacodynamics properties of chemotherapeutic agents, which can lead to efficient therapy. In this study, redox-responsive disulfide bond-containing amphiphilic heparin–chlorambucil conjugated polymeric prodrugs were designed and synthesized to enhance anti-tumor activities of chlorambucil. The conjugated prodrug could be self-assembled to form spherical vesicles with 61.33% chlorambucil grafting efficiency. The cell viability test results showed that the prodrug was biocompatible with normal cells (HaCaT) and that it selectively killed tumor cells (HeLa cells). The uptake of prodrugs by HeLa cells increased with time. Therefore, the designed prodrugs can be a better alternative as delivery vehicles for the chlorambucil controlled release in cancer cells. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Polymer Chemistry; https://dx.doi.org/10.3390/polym12010043 |
| DOI: |
10.3390/polym12010043 |
| الاتاحة: |
https://doi.org/10.3390/polym12010043 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.42644845 |
| قاعدة البيانات: |
BASE |