Academic Journal
Additional file 2 of Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer
| العنوان: | Additional file 2 of Identification of DNA methylation signatures associated with poor outcome in lower-risk Stage, Size, Grade and Necrosis (SSIGN) score clear cell renal cell cancer |
|---|---|
| المؤلفون: | Louis Y. El Khoury (10002103), Shuang Fu (342684), Ryan A. Hlady (3186816), Ryan T. Wagner (10002106), Liguo Wang (105768), Jeanette E. Eckel-Passow (228909), Erik P. Castle (10002109), Melissa L. Stanton (10002112), R. Houston Thompson (7926758), Alexander S. Parker (10002115), Thai H. Ho (9581682), Keith D. Robertson (10002118) |
| سنة النشر: | 2021 |
| المجموعة: | Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: | Medicine, Cell Biology, Genetics, Developmental Biology, Cancer, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Kidney cancer, ccRCC, DNA methylation, Epigenetics, SSIGN score, Prognostic marker, Reduced representation bisulfite sequencing (RRBS), Precision medicine |
| الوصف: | Additional file 2. Fig. S1. Global and DMCpG methylation comparison. Fig. S2. Unsupervised hierarchical clustering for cohort 1. Fig. S3 Browser views of the PTPRN2, PRDM16, MN1 and MOB2 genes. Fig. S4. Autosomal chromosome ideograms showing locations of DMCpGs for ccRCC cohorts 1 and 2 derived from RRBS. Fig. S5. Hexbin plot showing 460 DMCpGs from cohort 2 that are within 1kb of the 5929 DMCpGs from cohort 1. Fig. S6. Locus-specific confirmation of RRBS data at three genes (2 regions/gene) using bisulfite pyrosequencing. Fig. S7. PCA for the LTS fully methylated (n = 1204) and fully unmethylated (n = 821) CpGs. Fig. S8. Supervised hierarchical clustering of KIRC ccRCC samples (n=252) driven by methylation beta values of 22 CpGs (from Fig. 4c) significantly correlated with SSIGN score. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://figshare.com/articles/journal_contribution/Additional_file_2_of_Identification_of_DNA_methylation_signatures_associated_with_poor_outcome_in_lower-risk_Stage_Size_Grade_and_Necrosis_SSIGN_score_clear_cell_renal_cell_cancer/13605796 |
| DOI: | 10.6084/m9.figshare.13605796.v1 |
| الاتاحة: | https://doi.org/10.6084/m9.figshare.13605796.v1 |
| Rights: | CC BY + CC0 |
| رقم الانضمام: | edsbas.4191830D |
| قاعدة البيانات: | BASE |
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