Dissertation/ Thesis
Photoplethysmography for Non-Invasive Measurement of Cerebral Blood Flow: Calibration of a Wearable Custom-Made PPGSensor ; Fotopletismografy för Icke-Invasiv Mätning av Cerebralt Blodflöde: Kalibering av en Egentilverkad Bärbar PPG-Sensor
| العنوان: | Photoplethysmography for Non-Invasive Measurement of Cerebral Blood Flow: Calibration of a Wearable Custom-Made PPGSensor ; Fotopletismografy för Icke-Invasiv Mätning av Cerebralt Blodflöde: Kalibering av en Egentilverkad Bärbar PPG-Sensor |
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| المؤلفون: | Spadolini, Vittorio |
| بيانات النشر: | KTH, Medicinteknik och hälsosystem |
| سنة النشر: | 2024 |
| المجموعة: | Royal Inst. of Technology, Stockholm (KTH): Publication Database DiVA |
| مصطلحات موضوعية: | Cardiovascular Disease, Doppler Ultrasound, PPG, Blood Volume Flow, Image Processing II, Kardiovaskulär sjukdom, Doppler-ultraljud, Blodvolymflöde, Bildbehandling III, Medical Engineering, Medicinteknik, Medical Image Processing, Medicinsk bildbehandling, Medical Laboratory and Measurements Technologies, Medicinsk laboratorie- och mätteknik, Medical Equipment Engineering, Medicinsk apparatteknik |
| الوصف: | Stroke is an enormous global burden, six and a half-million people die fromstroke annually [1]. Effectively monitoring blood hemodynamic parameters suchas blood velocity and volume flow permits to help and cure people. This projectaimed to calibrate a custom-made wearable system for measuring cerebral bloodflow (CBF) using a photoplethysmography (PPG) sensor. The measurementswere validated using Doppler ultrasound as a reference method. Five (N=5)subjects (age = 24±1.41 years) were selected for the project. The PPG and Dopplerultrasound probe were placed above the left and right common carotid arteries(CCA), respectively. Measurements were taken simultaneously for 12 secondseach, with six consecutive measurements per subject and 2 time-synchronizedECG recordings. Subsequently, using an extraction algorithm the velocityenvelope (TAMEAN) was extracted from the Doppler image to obtain the bloodvolume flow (ml/min). After synchronization, the PPG signal output expressedin volts was calibrated to the corresponding volume, and a calibration curve wascreated.The extraction algorithm achieved remarkable results, with almost perfectcorrelation with the Doppler image reference, rT AM EAN =0.951 and rvolume=0.975demonstrating its reliability. Challenges encountered during postprocessingand synchronization highlighted the need for careful refinement in the projectframework. Despite successful signal processing and alignment techniques,calibration results were suboptimal due to synchronization difficulties andmotion artifacts. Limitations included impractical measurement locations andsusceptibility to movement artifacts. The calibration process did not yield theexpected outcomes and the project aim was not achieved. All the linear regressionmodels for each subject failed to accurately predict the volume flow based on themeasured voltages. Future work could focus on refining calibration procedures,improving synchronization methods, and expanding studies to include largercohorts. Although the wearable device was tested, the ... |
| نوع الوثيقة: | bachelor thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | TRITA-CBH-GRU; 2024:096 |
| الاتاحة: | http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-348699 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3B7E6CC9 |
| قاعدة البيانات: | BASE |
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