Academic Journal
Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest
| العنوان: | Ancient Dispersal of the Human Fungal Pathogen Cryptococcus gattii from the Amazon Rainforest |
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| المؤلفون: | Hagen, F., Ceresini, P.C., Polacheck, I., Ma, H., van Nieuwerburgh, F., Gabaldón, T., Kagan, S., Pursall, E.R., Hoogveld, H.L., van Iersel, L.J.J., Klau, G.W., Kelk, S.M., Bartlett, K.H., Stougie, L., Voelz, K., Pryszcz, L.P., Castañeda, E., Lazera, M., Mey, W., Deforce, D., Meis, J.F., May, R.C., Klaassen, C.H.W., Boekhout, T. |
| المصدر: | Hagen , F , Ceresini , P C , Polacheck , I , Ma , H , van Nieuwerburgh , F , Gabaldón , T , Kagan , S , Pursall , E R , Hoogveld , H L , van Iersel , L J J , Klau , G W , Kelk , S M , Bartlett , K H , Stougie , L , Voelz , K , Pryszcz , L P , Castañeda , E , Lazera , M , Mey , W , Deforce , D , Meis , J F , May , R .... |
| سنة النشر: | 2013 |
| الوصف: | Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals. © 2013 Hagen et al. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1371/journal.pone.0071148 |
| الاتاحة: | https://research.vu.nl/en/publications/08b345c3-4375-4138-9ba9-5ecf08d8eddc https://doi.org/10.1371/journal.pone.0071148 https://hdl.handle.net/1871.1/08b345c3-4375-4138-9ba9-5ecf08d8eddc |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.3451C0CC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0071148 |
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