The Pathogenomic Sequence Analysis of B. cereus and B. Thuringiensis isolates closely related to Bacillus anthracis
| العنوان: | The Pathogenomic Sequence Analysis of B. cereus and B. Thuringiensis isolates closely related to Bacillus anthracis |
|---|---|
| المؤلفون: | Han, C S, Xie, G, Challacombe, J F, Altherr, M R, Bhotika, S S, Bruce, D, Campbell, C S, Campbell, M L, Chen, J, Chertkov, O, Cleland, C, Dimitrijevic-Bussod, M, Doggett, N A, Fawcett, J J, Glavina, T, Goodwin, L A, Hill, K K, Hitchcock, P, Jackson, P J, Keim, P, Kewalramani, A R, Longmire, J, Lucas, S, Malfatti, S, McMurry, K, Meincke, L J, Misra, M, Moseman, B L, Mundt, M, Munk, A C, Okinaka, R T, Parson-Quintana, B, Reilly, L P, Richardson, P, Robinson, D L, Rubin, E, Saunders, E, Tapia, R, Tesmer, J G, Thayer, N, Thompson, L S, Tice, H, Ticknor, L O, Wills, P L, Gilna, P, Brettin, T S |
| سنة النشر: | 2021 |
| المجموعة: | SciTec Connect (Office of Scientific and Technical Information - OSTI, U.S. Department of Energy) |
| مصطلحات موضوعية: | 59 BASIC BIOLOGICAL SCIENCES, BACILLUS, BACILLUS CEREUS, GENES, REGULATIONS, STRUCTURAL CHEMICAL ANALYSIS, VIRULENCE |
| الوصف: | The sequencing and analysis of two close relatives of Bacillus anthracis are reported. AFLP analysis of over 300 isolates of B. cereus, B. thuringiensis and B. anthracis identified two isolates as being very closely related to B. anthracis. One, a B. cereus, BcE33L, was isolated from a zebra carcass in Nambia; the second, a B. thuringiensis, 97-27, was isolated from a necrotic human wound. The B. cereus appears to be the closest anthracis relative sequenced to date. A core genome of over 3,900 genes was compiled for the Bacillus cereus group, including B anthracis. Comparative analysis of these two genomes with other members of the B. cereus group provides insight into the evolutionary relationships among these organisms. Evidence is presented that differential regulation modulates virulence, rather than simple acquisition of virulence factors. These genome sequences provide insight into the molecular mechanisms contributing to the host range and virulence of this group of organisms. |
| نوع الوثيقة: | other/unknown material |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| Relation: | http://www.osti.gov/servlets/purl/885390; https://www.osti.gov/biblio/885390 |
| الاتاحة: | http://www.osti.gov/servlets/purl/885390 https://www.osti.gov/biblio/885390 |
| رقم الانضمام: | edsbas.313C79B3 |
| قاعدة البيانات: | BASE |
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