Academic Journal
Correlation between Trabecular Bone Score and Homocysteine Level in Rheumatoid Arthritis Patients on Anti-TNF Inhibitors
| العنوان: | Correlation between Trabecular Bone Score and Homocysteine Level in Rheumatoid Arthritis Patients on Anti-TNF Inhibitors |
|---|---|
| المؤلفون: | Florentina Ioniță-Radu, Iulia-Nadine Nicolau, Oana-Georgiana Petrache, Maria-Laura Groșeanu, Violeta-Claudia Bojincă, Maria-Magdalena Negru, Sandica Bucurică, Daniela Anghel |
| المصدر: | Life, Vol 14, Iss 4, p 463 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | rheumatoid arthritis, trabecular bone score, bone mineral density, homocysteine, 25-OH vitamin D, anti-TNF α agents, Science |
| الوصف: | Rheumatoid arthritis (RA) is an independent osteoporosis risk factor. Biologic and immunosuppressive treatment, and levels of homocysteine and 25-OH vitamin D may influence the trabecular bone score (TBS) in RA patients. We aimed to compare the effects of biological (b) and conventional synthetic (cs) disease-modifying anti-rheumatic drugs (DMARDs) on TBS in patients with RA and hyperhomocysteinemia (HHcy) or 25-OH vitamin D deficiency. Patients who had tests conducted for trabecular bone score, bone mineral density (BMD), homocysteine (Hcy) and 25-OH vitamin D at an interval of one year and met the inclusion criteria were enrolled in this retrospective study. Sixty-four patients with RA were enrolled and were divided into the following two groups: the first group (34 patients) had received treatment with bDMARDs and the second group (30 patients) had received csDMARDs. BDMARDs and csDMARDs had a positive influence on TBS and BMD. The best results were observed in the Adalimumab group ( p = 0.033). Hyperhomocysteinemia and 25-OH vitamin D deficiency led to lower TBS values. Both bDMARDs and csDMARDs positively affected TBS and BMD in RA patients. High homocysteine serum levels or 25-OH vitamin D deficiency had a negative impact on TBS and BMD after 12 months. Our study aims to show the potential benefits of anti-TNF α drugs on TBS. This impact appears to be strongly associated with serum 25-OH vitamin D and homocysteine levels. Anti-TNF drugs may increase bone mineral density and microstructure. As a result, they may minimize the incidence of fractures in RA patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2075-1729 |
| Relation: | https://www.mdpi.com/2075-1729/14/4/463; https://doaj.org/toc/2075-1729; https://doaj.org/article/d627238769e44d7e8094f565304a5ff9 |
| DOI: | 10.3390/life14040463 |
| الاتاحة: | https://doi.org/10.3390/life14040463 https://doaj.org/article/d627238769e44d7e8094f565304a5ff9 |
| رقم الانضمام: | edsbas.2D4BA3EF |
| قاعدة البيانات: | BASE |
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