Academic Journal
Pentafluorosulfanyl (SF(5)) as a superior (19)F magnetic resonance reporter group: signal detection and biological activity of teriflunomide derivatives
| العنوان: | Pentafluorosulfanyl (SF(5)) as a superior (19)F magnetic resonance reporter group: signal detection and biological activity of teriflunomide derivatives |
|---|---|
| المؤلفون: | Prinz, C., Starke, L., Ramspoth, T.F., Kerkering, J., Martos Riaño, V., Paul, J., Neuenschwander, M., Oder, A., Radetzki, S., Adelhoefer, S., Ramos Delgado, P., Aravina, M., Millward, J.M., Fillmer, A., Paul, F., Siffrin, V., von Kries, J.P., Niendorf, T., Nazaré, M., Waiczies, S. |
| بيانات النشر: | American Chemical Society |
| سنة النشر: | 2021 |
| المجموعة: | Max-Delbrueck-Center for Molecular Medicine, Berlin: MDC Repository |
| مصطلحات موضوعية: | Cardiovascular and Metabolic Diseases, Function and Dysfunction of the Nervous System, Technology Platforms, Topic 2: Molecular Processes and Therapies, Topic 3: Integrative Biomedicine |
| الوصف: | Fluorine ((19)F) magnetic resonance imaging (MRI) is severely limited by a low signal-to noise ratio (SNR), and tapping it for (19)F drug detection in vivo still poses a significant challenge. However, it bears the potential for label-free theranostic imaging. Recently, we detected the fluorinated dihydroorotate dehydrogenase (DHODH) inhibitor teriflunomide (TF) noninvasively in an animal model of multiple sclerosis (MS) using (19)F MR spectroscopy (MRS). In the present study, we probed distinct modifications to the CF(3) group of TF to improve its SNR. This revealed SF(5) as a superior alternative to the CF(3) group. The value of the SF(5) bioisostere as a (19)F MRI reporter group within a biological or pharmacological context is by far underexplored. Here, we compared the biological and pharmacological activities of different TF derivatives and their (19)F MR properties (chemical shift and relaxation times). The (19)F MR SNR efficiency of three MRI methods revealed that SF(5)-substituted TF has the highest (19)F MR SNR efficiency in combination with an ultrashort echo-time (UTE) MRI method. Chemical modifications did not reduce pharmacological or biological activity as shown in the in vitro dihydroorotate dehydrogenase enzyme and T cell proliferation assays. Instead, SF(5)-substituted TF showed an improved capacity to inhibit T cell proliferation, indicating better anti-inflammatory activity and its suitability as a viable bioisostere in this context. This study proposes SF(5) as a novel superior (19)F MR reporter group for the MS drug teriflunomide. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | http://edoc.mdc-berlin.de/21013/1/21013oa.pdf; http://edoc.mdc-berlin.de/21013/7/21013suppl.pdf; Pentafluorosulfanyl (SF(5)) as a superior (19)F magnetic resonance reporter group: signal detection and biological activity of teriflunomide derivatives. Prinz, C. and Starke, L. and Ramspoth, T.F. and Kerkering, J. and Martos Riaño, V. and Paul, J. and Neuenschwander, M. and Oder, A. and Radetzki, S. and Adelhoefer, S. and Ramos Delgado, P. and Aravina, M. and Millward, J.M. and Fillmer, A. and Paul, F. and Siffrin, V. and von Kries, J.P. and Niendorf, T. and Nazaré, M. and Waiczies, S. ACS Sensors 6 (11): 3948–3956. 26 November 2021 |
| DOI: | 10.1021/acssensors.1c01024 |
| الاتاحة: | http://edoc.mdc-berlin.de/21013/ https://edoc.mdc-berlin.de/21013/ http://edoc.mdc-berlin.de/21013/1/21013oa.pdf http://edoc.mdc-berlin.de/21013/7/21013suppl.pdf https://doi.org/10.1021/acssensors.1c01024 |
| Rights: | cc_by_4 |
| رقم الانضمام: | edsbas.264FE498 |
| قاعدة البيانات: | BASE |
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