Academic Journal
Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients
| العنوان: | Chromosome banding analysis and genomic microarrays are both useful but not equivalent methods for genomic complexity risk stratification in chronic lymphocytic leukemia patients |
|---|---|
| المؤلفون: | Ramos Campoy, Silvia, Puiggros Metje, Anna Maria, Gimeno Vázquez, Eva, Espinet Solà, Blanca |
| بيانات النشر: | Ferrata Storti Foundation |
| سنة النشر: | 2022 |
| المجموعة: | UPF Digital Repository (Universitat Pompeu Fabra, Barcelona) |
| الوصف: | Genome complexity has been associated with poor outcome in patients with chronic lymphocytic leukemia (CLL). Previous cooperative studies established five abnormalities as the cut-off that best predicts an adverse evolution by chromosome banding analysis (CBA) and genomic microarrays (GM). However, data comparing risk stratification by both methods are scarce. Herein, we assessed a cohort of 340 untreated CLL patients highly enriched in cases with complex karyotype (CK, 46.5%) with parallel CBA and GM studies. Abnormalities found by both techniques were compared. Prognostic stratification in three risk groups based on genomic complexity [0-2, 3-4 and ≥5 abnormalities] was also analyzed. No significant differences in the percentage of patients classified into each category were detected, but only a moderate agreement was observed between methods when focusing in individual cases (κ=0.507; p. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Haematologica. 2022;107(3):593-603; http://hdl.handle.net/10230/47912; http://dx.doi.org/10.3324/haematol.2020.274456 |
| DOI: | 10.3324/haematol.2020.274456 |
| الاتاحة: | http://hdl.handle.net/10230/47912 https://doi.org/10.3324/haematol.2020.274456 |
| Rights: | © 2021 Ferrata Storti Foundation. Papers in Haematologica are published under a Creative Commons license CC BY-NC-ND. According to this license, an article may be copied, displayed, distributed, republished or otherwise reused provided the reuse is not an adaptation or a modification and the integrity of the original paper is maintained. This license does not allow for any kind of commercial use of the paper. For more details, see About Haematologica. ; https://creativecommons.org/licenses/by-nc-nd/4.0 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.21ACEA32 |
| قاعدة البيانات: | BASE |
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